D-Configured Antimicrobial Peptides for Drug-Resistant Infections

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Solution Overview

Problem

The emergence of multi-drug resistant (MDR) and extremely drug-resistant (XDR) bacterial pathogens has rendered common infections untreatable with standard antibiotics, necessitating the development of new antimicrobial agents to combat these resistant strains.

Innovation Solution

Development of stable peptide-based antibiotics with specific amino acid sequences, including those in D-configuration, exhibiting improved antimicrobial activity, stability, and therapeutic index, administered in various forms to treat infections caused by MDR and XDR pathogens.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If standard antibiotics are used to treat infections, then common infections can be treated effectively, but they become ineffective against MDR and XDR bacterial pathogens

Engineering Contradiction:

Improveantimicrobial effectivenessVSAvoidspectrum of activity against resistant strains

Core Design Contradiction:

ReliabilityVSAdaptability or versatility

Solution Approach 1:

The patent changes the chemical parameters of antimicrobial agents by using peptide-based structures with specific amino acid sequences and D-configuration instead of traditional antibiotics, enabling activity against MDR and XDR pathogens while maintaining effectiveness

Inventive Principle:

Principle #35Parameter changes

2Reliability

If peptide-based antibiotics are designed with improved antimicrobial activity, then efficacy against resistant strains increases, but stability may be compromised

Engineering Contradiction:

Improveantimicrobial activityVSAvoidpeptide stability

Core Design Contradiction:

ReliabilityVSStability of the object's composition

Solution Approach 1:

The patent changes the stereochemical parameter of amino acids from L-configuration to D-configuration in the peptide structure, which significantly improves stability against proteolytic degradation while preserving or enhancing antimicrobial activity

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The patent creates composite peptide structures combining specific amino acid sequences with D-configuration residues, achieving both high antimicrobial activity and improved stability through the synergistic combination of these features

Inventive Principle:

Principle #40Composite materials

3Stability of the object's composition

If peptide structure is modified to enhance stability, then resistance to degradation improves, but hemolytic activity may increase

Engineering Contradiction:

Improveproteolytic stabilityVSAvoidhemolytic activity

Core Design Contradiction:

Stability of the object's compositionVSObject-affected harmful factors

Solution Approach 1:

The patent applies local quality modification by specifically changing certain amino acid residues to D-configuration at key positions in the peptide sequence, providing stability enhancement while minimizing disruption to the peptide's interaction with bacterial membranes and reducing hemolytic activity

Inventive Principle:

Principle #3Local quality

Data Source

PatentUS20250368700A1Novel peptide for treating an infectious disease or condition

Publication Date: 2025.12.04 OMNIX MEDICAL LTD

AI summary

The invention provides a peptide having antimicrobial activity comprising the amino acid sequence as set forth in SEQ ID No. 1 (FLNALKNFAKTAGKRLKSLLN), wherein at least one, part, or all of the amino acids of SEQ ID No. 1 are in D-configuration. Further provided are methods of using the same for the treatment or prevention of an infectious disease or condition.