D-psicose Sweetener Suppresses Blood Glucose Peaks
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Solution Overview
Problem
The rapid increase in blood glucose levels caused by consuming starch or sucrose leads to excessive insulin secretion, potentially resulting in pancreas exhaustion and the onset of diabetes mellitus, particularly in individuals with obesity, as it stimulates insulin secretion rapidly and can lead to insulin deficiency over time.
Innovation Solution
Incorporating D-psicose into foods and drinks as a sweetener, seasoning, or food additive to suppress abnormal intra-day increases in plasma glucose concentration by enhancing glucose uptake in the liver and muscle, inhibiting sugar digestive enzymes, and stimulating insulin secretion, thereby regulating blood glucose levels.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Use of energy by moving object
If starch or sucrose is consumed to provide energy and satisfaction, then blood glucose level increases rapidly, but this causes excessive insulin secretion that may lead to pancreas exhaustion and diabetes mellitus
Solution Approach 1:
The patent changes the chemical composition parameter by replacing conventional sugars (starch, sucrose) with D-psicose, a rare sugar that has different metabolic properties. This parameter change results in reduced blood glucose increase and lowered insulin secretion while maintaining energy provision and sweetness, thereby preventing pancreas exhaustion
Solution Approach 2:
The patent converts the harmful rapid glucose spike and excessive insulin secretion into a beneficial controlled response. By using D-psicose, the harmful effect of hyperglycemia-induced insulin overload is transformed into a mild, sustained blood glucose regulation that protects the pancreas while still providing energy
2Ease of manufacture
If conventional sugars are used as sweeteners to provide sweetness and energy, then blood glucose level increases rapidly, but this stimulates excessive insulin secretion
Solution Approach 1:
The patent changes the sugar type parameter from conventional high-glycemic sugars to D-psicose, which has a lower glycemic index. This parameter change maintains the sweetness function while significantly reducing the quantity of insulin secretion stimulated, as D-psicose causes a more gradual and moderate blood glucose increase
3Quantity of substance
If high sugar intake is consumed to satisfy taste and energy needs, then blood glucose level increases, but this leads to insulin deficiency over time due to pancreas exhaustion
Solution Approach 1:
The patent changes the carbohydrate composition parameter by substituting conventional sugars with D-psicose. This parameter change allows maintaining adequate energy and taste satisfaction while preventing the development of insulin deficiency, as D-psicose does not cause the same degree of pancreatic stress as conventional sugars
Solution Approach 2:
The patent enables continuous sugar consumption without the harmful accumulation effect. By using D-psicose, the body can continuously obtain energy and sweetness without triggering the progressive insulin deficiency that occurs with conventional high-sugar diets, thus maintaining reliable insulin secretion over time
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
D-psicose effectively reduces the peak blood glucose levels and insulin secretion, preventing pancreas exhaustion and insulin deficiency, making it beneficial for managing diabetes mellitus and related conditions like obesity and arteriosclerosis.
Implementation Method 1
the elevation of the uptake of blood glucose in liver and muscle
Implementation Method 2
the inhibition of sugar digestive enzymes in the gastrointestinal tract
Implementation Method 3
the stimulation of insulin secretion from pancreas
Data Source
AI summary
A novel use of D-psicose (for suppressing the abnormal intra-day increase of blood glucose level) is provided. A composition containing D-psicose as the active component and for use in suppressing the abnormal intra-day increase of plasma glucose concentration. The composition is a composition in blend with D-psicose and/or a derivative thereof. The composition is in a form selected from sweeteners, seasonings, food additives, food materials, food and drink products, health food and drink products, pharmaceutical products, and feeds and blended with D-psicose, and/or a derivative thereof as the active component, for use in preventing and therapeutically treating diseases requiring the saving of insufficient insulin, the amelioration of insulin sensitivity and the amelioration of hyperglycemia, and/or diseases of which the symptoms can be ameliorated via the suppression of the abnormal intra-day increase of plasma glucose concentration or of which the onset can be prevented via the suppression thereof, such as diabetes mellitus, occult diabetic states, obesity, hyperglycemia, and/or arteriosclerosis. A method for using D-psicose in suppressing the abnormal intra-day increase of plasma glucose concentration, comprising giving D-psicose at given times to suppress the abnormal increase of plasma glucose concentration throughout the day.