Dabigatran Dosage Calculator for Renal Function Variability
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Solution Overview
Problem
Current dabigatran dosage methods lack flexibility and accuracy, particularly for patients with renal impairment, leading to underdosing or overdosing, and insufficient monitoring exacerbates these issues, increasing thrombotic and hemorrhagic risks.
Innovation Solution
A computer-implemented method using a dosage calculator derived from a plasma level prediction model processes patient data, including kidney function metrics, to determine personalized dabigatran dosages, accounting for variability in drug plasma levels.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If fixed dosage regimens are used for dabigatran, then ease of operation is improved, but manufacturing precision deteriorates due to inability to account for inter-subject variability in plasma levels
Solution Approach 1:
The patent applies parameter changes by adjusting the dosage amount based on measured plasma levels of dabigatran. The system dynamically modifies dosing parameters (amount, frequency) to maintain plasma concentrations within the therapeutic window, resolving the contradiction between ease of fixed dosing and precision of plasma level control
Solution Approach 2:
The patent implements feedback control by measuring plasma dabigatran levels and using this information to adjust subsequent dosing decisions. This closed-loop system continuously monitors outcomes and modifies dosage regimens accordingly, achieving both ease of operation through systematic guidance and precision through adaptive adjustment
2Device complexity
If standardized dosing guidelines are applied, then device complexity is reduced, but measurement precision deteriorates due to insufficient accounting for individual patient factors
Solution Approach 1:
The system changes dosing parameters based on individual patient factors including renal function, age, weight, and measured plasma levels. This allows the relatively simple dosing system to achieve high measurement precision by adapting to each patient's unique characteristics rather than applying uniform guidelines
3Manufacturing precision
If frequent plasma level monitoring is implemented, then manufacturing precision is improved through better dosage adjustment, but loss of time increases due to additional monitoring requirements
Solution Approach 1:
The patent applies preliminary action by establishing baseline plasma levels before initiating therapy and performing early monitoring to quickly characterize individual pharmacokinetics. This allows the system to achieve high dosage accuracy while minimizing total monitoring time by intensive early monitoring followed by less frequent subsequent measurements
Data Source
AI summary
A computer implemented method for determining a dosage of dabigatran for administering to a patient, the method comprising: receiving patient data relating to a patient, wherein the patient data includes a kidney function metric; processing the patient data with a dosage calculator to determine the dosage of dabigatran for administering to the patient, wherein the dosage calculator is derived from a plasma level prediction model; and indicating the dosage.