Dialdehyde Cellulose Hemostatic Textile with Immobilized Gelatin
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Existing hemostatic materials face challenges with low degree of oxidation of cellulose, leading to ineffective binding of components, premature activation of fibrinogen by thrombin, and safety concerns due to animal or human proteins, which result in incomplete covalent binding and risk of infection from blood-borne pathogens.
Innovation Solution
A hemostatic material based on dialdehyde cellulose with immobilized gelatin, chitosan, tranexamic acid, lysozyme, and antimicrobial agents, which eliminates thrombin and fibrinogen, ensuring covalent binding of components and reducing the risk of infection, while providing enhanced coagulation and antimicrobial properties.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If cellulose with low degree of oxidation is used, then safety is improved (avoiding blood-borne pathogens), but binding capability deteriorates (components only physically mixed, not covalently bound)
Solution Approach 1:
The patent applies parameter changes by optimizing the degree of oxidation of cellulose to a specific range (3-8%) to simultaneously achieve covalent binding capability and safety. This quantitative parameter adjustment resolves the contradiction between binding strength and safety by finding the optimal oxidation level that provides both properties.
Solution Approach 2:
The patent creates a composite hemostatic material combining oxidized cellulose (for covalent binding), gelatin (for coagulation), chitosan (for antimicrobial activity), and other components. This composite approach allows each component to contribute its strengths, achieving both effective binding and safety without requiring extreme oxidation levels.
2Productivity
If thrombin and fibrinogen are used together, then coagulation effectiveness is improved, but stability deteriorates (premature activation and fibrinolysis)
Solution Approach 1:
The patent extracts thrombin from the formulation, eliminating the source of premature fibrinogen activation and fibrinolysis. By removing this problematic component while retaining fibrinogen and other coagulation factors, the patent achieves composition stability while maintaining coagulation effectiveness through alternative mechanisms.
Solution Approach 2:
The patent introduces gelatin and chitosan as intermediary substances that facilitate coagulation and stabilize the composition without causing premature activation. These intermediaries mediate the coagulation process safely, replacing the direct thrombin-fibrinogen interaction that causes instability.
3Manufacturing precision
If complex multi-stage production process is used, then binding completeness is improved, but device complexity increases
Solution Approach 1:
The patent merges multiple production stages into a single impregnation step where all active components (gelatin, chitosan, tranexamic acid, etc.) are simultaneously applied to the oxidized cellulose substrate. This consolidation achieves complete binding while dramatically simplifying the production process from multiple stages to one integrated operation.
Solution Approach 2:
The patent performs preliminary oxidation of cellulose to the optimal degree (3-8%) before impregnation, preparing the substrate in advance to ensure complete covalent binding of all components in a single subsequent step. This preliminary preparation enables simplified downstream processing while maintaining binding completeness.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The material effectively accelerates bleeding cessation, stabilizes clots, and maintains wound sterility, reducing the risk of fibrinolysis and infection, with a simplified production process and improved safety profile.
Implementation Method 1
ensuring covalent binding of components
Implementation Method 2
Only calcium ions become bound with COOH—groups with the intermediacy of ionic forces
Implementation Method 3
hemostatic material to stop bleeding
Data Source
AI summary
A hemostatic textile material to stop bleeding comprising a dialdehyde cellulose (DAC) carrier wherein the degree of oxidation of the dialdehyde cellulose varies from about 1.5% to 12%; and a blood coagulation factor selected from the group consisting of chitosan and gelatin; the blood coagulation factor being chemically immobilized thereon; and further optionally comprising a bacteriolytic agent selected from the group consisting of a lysozyme enzyme, silver nitrate, and chlorhexidine; and further optionally comprising a selected component that prevents hemolysis, the component selected from the group consisting of tranexamic acid or ε-aminocaproic acid chemically immobilized thereon.