Spherical Calcium Phosphate via Dual Asymmetric Centrifugation

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Solution Overview

Problem

The existing methods for producing spherical calcium phosphate particles for bone graft substitutes are inefficient and lack simplicity, making it challenging to achieve controlled production for enhanced injectability and handling properties.

Innovation Solution

The method involves subjecting a composition of calcium phosphate, magnesium phosphate, or strontium phosphate to dual asymmetric centrifugation (DAC) with specific processing steps and additives, such as biopolymers, to produce substantially spherical particles with controlled size and mechanical properties.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Shape

If conventional methods (precipitation, spray drying, electrospraying, etc.) are used to produce spherical calcium phosphate particles, then spherical shape can be achieved, but the production process becomes complex and inefficient

Engineering Contradiction:

Improvespherical particle shapeVSAvoidproduction process complexity

Core Design Contradiction:

ShapeVSDevice complexity

Solution Approach 1:

The invention extracts and isolates the essential function of spherical particle formation from complex multi-step processes. By using dual asymmetric centrifugation as a single unit operation, the patent eliminates the need for multiple separate processes (precipitation, drying, sphericalization) while achieving the same spherical particle outcome, thus reducing device complexity while maintaining shape quality

Inventive Principle:

Principle #2Taking out (Extraction)

Solution Approach 2:

The invention replaces complex mechanical systems (spray drying equipment, electrospraying apparatus, flame synthesis equipment) with a simpler dual asymmetric centrifugation system. This mechanical substitution achieves spherical particle formation through centrifugal forces and asymmetric motion patterns, eliminating the need for complex thermal, electrical, or chemical systems while maintaining production efficiency

Inventive Principle:

Principle #28Mechanics substitution (Replace mechanical system)

2Ease of operation

If spherical particles are used to enhance injectability, then handling properties improve, but controlled production remains challenging

Engineering Contradiction:

Improveinjectability and handling propertiesVSAvoidcontrolled production capability

Core Design Contradiction:

Ease of operationVSEase of manufacture

Solution Approach 1:

The invention employs dynamic asymmetric centrifugation with varying rotational speeds and patterns to control particle formation in real-time. By dynamically adjusting the centrifugation parameters during the process, the system achieves both spherical shape (for injectability) and controlled production rates, resolving the contradiction between ease of operation and ease of manufacture

Inventive Principle:

Principle #15Dynamics

Solution Approach 2:

The invention controls particle production by systematically changing physical parameters (centrifugal force, rotation speed, solution concentration, pH) during the dual asymmetric centrifugation process. These parameter changes enable precise control over particle size, shape, and production rate simultaneously, achieving both improved handling properties and controlled manufacture

Inventive Principle:

Principle #35Parameter changes

3Manufacturing precision

If multiple processing steps are used to achieve spherical particles, then particle quality improves, but production efficiency decreases

Engineering Contradiction:

Improveparticle size and shape controlVSAvoidproduction efficiency

Core Design Contradiction:

Manufacturing precisionVSProductivity

Solution Approach 1:

The invention merges multiple discrete processing steps (precipitation, sphericalization, size control) into a single integrated dual asymmetric centrifugation operation. This consolidation maintains manufacturing precision by controlling all parameters within one system while dramatically improving productivity by eliminating intermediate steps and transfer operations

Inventive Principle:

Principle #5Merging (Combining)

Solution Approach 2:

The invention implements continuous particle formation and sphericalization within the dual asymmetric centrifugation system, eliminating batch-to-batch interruptions. The continuous action maintains precise particle control throughout the process while maximizing production efficiency through uninterrupted operation

Inventive Principle:

Principle #20Continuity of useful action

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

This approach results in spherical particles with improved mechanical strength and controlled size distribution, enhancing the injectability and handling properties of bone graft substitutes, facilitating their use in dental and orthopedic applications.

Implementation Method 1

subjecting a composition comprising at least one of calcium phosphate, magnesium phosphate, or strontium phosphate to dual asymmetric centrifugation (DAC) to produce substantially spherical particles

Methodology Applied

Scientific EffectCentrifugal force: Centrifugal Force

Data Source

PatentUS11241515B2Controlled production of spherical calcium phosphate, magnesium phosphate, and strontium phosphate particles for dental and orthopedic applications using dual asymmetric centrifugation

Publication Date: 2022.02.08 OSTEONOVUS LLC

AI summary

Described is a method for the production of substantially spherical calcium phosphate particles that involves subjecting a composition comprising calcium phosphate to dual asymmetric centrifugation (DAC). Also described are products of the method.