DBM Delivery System with Porous Mesh Bag for Sustained Bone Growth
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Solution Overview
Problem
Current demineralized bone matrix (DBM) delivery systems have limitations, including rapid degradation of osteogenic activity, which reduces the effectiveness of bone grafts in promoting bone growth, as the active factors are available for a short duration, and existing methods do not effectively induce new bone formation throughout the graft material.
Innovation Solution
A delivery system comprising a covering that retains and mixes DBM particles/fibers with bone graft materials and bioactive agents, such as autologous bone and growth factors, to facilitate prolonged interaction and induce bone growth throughout the graft rather than just along the surface, using a porous mesh bag with access ports and sealing mechanisms for efficient delivery.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If DBM is delivered using conventional mesh bags, then the DBM is contained and delivered to the surgical site, but the active factors in the DBM are rapidly degraded and osteogenic activity is lost within 6-24 hours
Solution Approach 1:
The patent applies preliminary action by pre-coating DBM particles with bone graft material and bioactive agents before delivery. This preparation ensures that as soon as the DBM is implanted, the bioactive agents are already in place to stimulate osteogenic activity, compensating for the rapid degradation of native DBM factors. The bone graft material serves as a sustained-release carrier that maintains osteogenic stimulation throughout the healing process.
Solution Approach 2:
The patent creates a composite material system by combining DBM particles with bone graft material and bioactive agents. This composite structure allows the DBM to provide immediate osteogenic signaling while the bone graft material matrix provides sustained release of growth factors and other bioactive components, extending the duration of osteogenic activity beyond the 6-24 hour limitation of conventional DBM alone.
2Ease of operation
If DBM is placed in a mesh bag, then the DBM is contained, but additional bone graft materials must be placed separately underneath or on top, which does not induce new bone formation throughout the graft material
Solution Approach 1:
The patent merges multiple functions into a single delivery system by coating DBM particles with bone graft material and bioactive agents. This unified approach eliminates the need for separate placement of additional materials and ensures that bone formation is induced throughout the entire graft material, not just at the surface or in separate layers.
Solution Approach 2:
The patent applies local quality by ensuring that each DBM particle is individually coated with bone graft material and bioactive agents. This creates uniform osteogenic activity throughout the entire graft material, rather than having active regions only at the surface or in separate layers, thereby inducing new bone formation consistently throughout the implant.
3Productivity
If DBM particles are delivered without mixing with other bone graft materials, then the delivery is simple, but the efficacy and consistency of bone growth promotion is reduced
Solution Approach 1:
The patent applies preliminary action by pre-mixing DBM particles with bone graft material and bioactive agents in a controlled manufacturing process. This ensures uniform distribution and consistent efficacy without requiring complex mixing procedures during surgery, thereby maintaining surgical simplicity while maximizing bone regeneration efficiency.
Data Source
AI summary
A delivery system comprising a covering containing at least a first substance for release to a surgical site is provided. The covering includes an elongated containment portion having at least one compartment, wherein the covering retains the first substance for mixing with a second substance prior to delivery at a surgical site. The covering may be a single or multi compartment structure capable of retaining at least partially the mixture of the at least first and second substances until the covering is placed at the surgical site. The elongated containment portion of the covering includes a first end and second end opposite each other, wherein at least one end defines an access port configured to receive a device capable of delivering a second substance into the elongated containment portion for mixing with the first substance prior to or during the surgical procedure.