DBM-Perfluorocarbon Bone Graft for Enhanced Osteogenesis
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Solution Overview
Problem
Current bone grafting techniques face limitations in enhancing osteogenesis, osteoconduction, and osteoinduction, particularly in elderly patients, due to decreased osteogenic cell numbers and inadequate vascular and cellular migration on scaffolds.
Innovation Solution
A composition combining demineralized bone matrix (DBM) with perfluorocarbons, such as perfluorodecalin, perfluorohexane, or perfluorotributylamine, which acts as an oxygen carrier to enhance bone formation by improving osteogenesis, osteoconduction, and osteoinduction, and is supplemented with handling agents like saline or polyoxamers for better handling characteristics.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If DBM is used alone for bone grafting, then the basic osteoconductive structure is provided, but the osteogenic activity and bone formation rate are insufficient, especially in elderly patients
Solution Approach 1:
The patent changes the chemical composition parameters of the bone graft by incorporating perfluorocarbon (a fluorinated compound) into the DBM matrix. This parameter change enhances osteogenic activity by providing a different chemical environment that stimulates bone formation, thereby improving the bone formation rate without relying solely on osteogenic cell availability
Solution Approach 2:
The patent creates a composite material by combining DBM with perfluorocarbon. This composite structure integrates the osteoconductive properties of DBM with the osteogenic stimulatory effects of perfluorocarbon, resulting in a material that provides both structural support and enhanced bone formation capability
2Productivity
If the DBM composition is optimized for bone formation, then osteogenic activity increases, but the handling characteristics for surgical application deteriorate
Solution Approach 1:
The patent adjusts the concentration parameter of perfluorocarbon in the DBM composition to optimize both osteogenic activity and handling characteristics. By controlling the amount of perfluorocarbon incorporated, the formulation achieves enhanced bone formation while maintaining workable physical properties for surgical application
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The DBM-perfluorocarbon composition significantly increases bone formation compared to DBM alone, demonstrating enhanced osteogenic activity without the need for supplemental oxygen, and improves handling characteristics for surgical applications.
Implementation Method 1
a perfluorocarbon which acts as an oxygen carrier to enhance bone formation
Data Source
AI summary
An improved composition for inducing bone growth is provided that is a mixture of DBM and a perfluorocarbon oxygen carrier. Injection/implantation of a composition of DBM and a perfluorocarbon results in enhancement of bone formation.