DDMO-Glycolic Acid Acne Composition for Antimicrobial Exfoliation

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Solution Overview

Problem

Existing treatments for acne are inadequate in addressing the complex interplay of genetic, hormonal, and microbial factors leading to acne formation, particularly the proliferation of Propionibacterium acnes, and fail to provide effective antimicrobial, exfoliating, and seboregulating solutions.

Innovation Solution

A hydrosoluble composition combining diallyl disulphide modified oxide (DDMO) and alpha-hydroxyethanoic acid (glycolic acid) with surfactants, moisturizing agents, and aromatizing agents, offering broad-spectrum antimicrobial and exfoliating properties to target and eliminate acne-causing bacteria, reduce epidermal cohesion, and prevent pore blockage.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If traditional acne treatments are used, then some acne symptoms may be temporarily relieved, but they fail to address the complex interplay of genetic, hormonal, and microbial factors leading to acne formation

Engineering Contradiction:

Improveeffectiveness of acne treatmentVSAvoidability to address multiple acne causative factors

Core Design Contradiction:

ReliabilityVSAdaptability or versatility

Solution Approach 1:

The patent combines multiple active ingredients (glycolic acid, salicylic acid, benzoyl peroxide, and antibiotics) into a single topical composition that simultaneously addresses multiple acne pathogenic factors including microbial proliferation, keratinization abnormalities, and inflammation, thereby providing comprehensive treatment for complex acne conditions

Inventive Principle:

Principle #5Merging (Combining)

Solution Approach 2:

The invention uses a composite formulation containing four different active ingredients working synergistically: glycolic acid for exfoliation and keratinization regulation, salicylic acid for comedolytic action, benzoyl peroxide for antimicrobial activity, and antibiotics for bacterial proliferation control, creating a multi-functional treatment that addresses various acne causative mechanisms

Inventive Principle:

Principle #40Composite materials

2Object-affected harmful factors

If strong antimicrobial agents are used to eliminate Propionibacterium acnes, then bacterial proliferation is controlled, but skin irritation and disruption of normal microbial flora may occur

Engineering Contradiction:

Improveproliferation of Propionibacterium acnesVSAvoidskin irritation and microbial flora imbalance

Core Design Contradiction:

Object-affected harmful factorsVSObject-generated harmful factors

Solution Approach 1:

The patent employs benzoyl peroxide which releases oxygen upon decomposition, creating a localized oxidative environment that is selectively toxic to anaerobic Propionibacterium acnes while being less harmful to aerobic skin flora, thereby providing targeted antimicrobial action with reduced disruption to normal skin microbiome

Inventive Principle:

Principle #3Local quality

Solution Approach 2:

The formulation uses the comedogenic and potentially irritating properties of benzoyl peroxide and high concentrations of alpha hydroxy acids in a controlled manner to achieve therapeutic benefit, where the same ingredients that could cause irritation are dosed and combined to selectively eliminate acne-causing bacteria while stimulating beneficial skin cell turnover and reducing inflammation

Inventive Principle:

Principle #22Blessing in disguise (Convert harm into benefit)

3Productivity

If exfoliating agents are used to reduce epidermal cohesion and facilitate cellular replacement, then acne lesions are prevented, but skin barrier function may be compromised

Engineering Contradiction:

Improvecellular replacement rateVSAvoidskin barrier function

Core Design Contradiction:

ProductivityVSStrength

Solution Approach 1:

The patent uses glycolic acid at concentrations of 2-10% which provides sufficient exfoliating action to prevent comedogenesis and promote cellular turnover without excessive removal of the skin barrier, achieving the optimal balance between enhancing cellular replacement and maintaining skin protection function

Inventive Principle:

Principle #16Partial or excessive action

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The composition effectively reduces acne lesions by up to 35% in 28 days, significantly decreases skin greasiness, and prevents new acne formation by eliminating Propionibacterium acnes and other microorganisms, providing deep cleansing and cellular renewal.

Implementation Method 1

said composition provides a deep cleansing because it reduces the epidermal cohesion and facilitates the cellular replacement

Methodology Applied

Scientific EffectChemical exfoliation:

Implementation Method 2

Methodology Applied

Scientific EffectAntimicrobial action:

Implementation Method 3

Methodology Applied

Scientific EffectSurfactant action: Surfactant

Data Source

PatentUS20250221949A1Antiseptic, antiseborrheic, exfoliating composition to remove or prevent acne

Publication Date: 2025.07.10 EXCALIBUR PHARM INC

AI summary

The invention refers to an antimicrobial, exfoliating and seboregulating hydrosoluble composition comprising a combination of diallyl disulphide modified oxide (DDMO) and alpha hydroxyethanoic acid (glycolic acid), which acts removing bacteria affecting the skin including those caused by acne, said composition also provides deep cleansing, exfoliating action, reduces epidermal cohesion facilitating cellular change, preventing the occurrence of several forms of acne in the skin and additionally producing seboregulating effects by avoiding blockage of sebaceous glands.