Decellularized Muscle Matrix for Regeneration
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Solution Overview
Problem
Current muscle regenerative procedures face challenges such as excess inflammation, scar tissue formation, and muscle loss at donor sites due to the use of muscle transplants, and there is a need for improved methods to manage muscle repair, regeneration, and augmentation, especially for individuals with low muscle mass or those requiring increased strength or aesthetics.
Innovation Solution
Decellularized muscle matrices that retain some myofibers or myosin are used to create muscle implants, which can be in particulate or sheet form, allowing for controlled decellularization to maintain structural integrity and promote functional muscle regeneration, augmentation, and treatment of muscle defects.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If muscle transplants are used for muscle repair and regeneration, then muscle mass can be restored, but excess inflammation and scar tissue formation occur
Solution Approach 1:
The patent extracts and removes cells from muscle tissue while preserving the extracellular matrix and myofibers, creating a decellularized muscle matrix that maintains structural integrity and regenerative capacity without the inflammatory response associated with cellular muscle transplants
Solution Approach 2:
The decellularized muscle matrix acts as an intermediary scaffold that provides structural support and biochemical signals for muscle regeneration without introducing foreign cells that would trigger immune rejection and inflammation
2Quantity of substance
If muscle allografts are harvested from donor sites, then muscle repair can be achieved, but muscle loss occurs at the donor site
Solution Approach 1:
The patent creates a copy of the muscle extracellular matrix and myofiber structure without requiring live muscle tissue, using decellularized matrix that can be processed from non-donatable sources while preserving the regenerative template
3Object-generated harmful factors
If complete decellularization is performed to remove all cells, then immune rejection is reduced, but structural integrity and regenerative capacity are lost
Solution Approach 1:
The patent applies selective decellularization that differentiates between cell types and locations, removing immunogenic cells while preserving myofibers and extracellular matrix structures that provide structural integrity and regenerative signals
4Object-generated harmful factors
If enzyme treatment is increased to improve decellularization, then cell removal is enhanced, but myofiber retention decreases
Solution Approach 1:
The patent applies partial decellularization using controlled enzyme treatment that removes sufficient cells to reduce immunogenicity while stopping before complete decellularization to preserve myofiber content and structural integrity
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The use of decellularized muscle matrices promotes increased muscle regeneration, reduces inflammation, and enhances muscle mass and functional characteristics, providing a viable solution for muscle defects and aesthetic enhancements without the drawbacks of traditional muscle transplants.
Implementation Method 1
contacting the at least one muscle sample with an enzyme; decellularizing the at least one muscle sample to produce at least one decellularized muscle matrix
Data Source
AI summary
Disclosed herein are muscle implants and methods of making muscle implants comprising one or more decellularized muscle matrices. The muscle matrices can be provided in a particulate form suitable for injection or implantation.