Deep Learning OCT Conversion to Virtual Stained Skin Images

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Solution Overview

Problem

Stained images obtained through pathological sections are the authoritative standard for diagnosing skin lesions but are destructive and time-consuming, while optical coherence tomography (OCT) provides non-invasive imaging that dermatologists are not familiar with.

Innovation Solution

A system and method using deep learning to convert OCT images of skin tissue into stained images by establishing a first deep generative model to learn a mapping relationship between OCT and stained image sets, enabling bidirectional conversion.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Measurement precision

If stained images are obtained through pathological sections, then diagnostic accuracy is improved, but tissue destruction and time consumption increase

Engineering Contradiction:
Improvediagnostic accuracyVSAvoidpreparation time
Core Design Contradiction:
Measurement precisionVSLoss of time

Solution Approach 1:

The patent uses deep learning models to generate synthetic stained images from OCT images, creating virtual copies of stained tissue sections without actual staining. The generative model learns the mapping relationship between OCT and stained image domains, producing realistic stained image representations that preserve diagnostic information while eliminating the time-consuming and destructive staining process.

Inventive Principle:
Principle #26Copying

Solution Approach 2:

The patent replaces the mechanical/chemical staining process with a computational deep learning system. Instead of physically staining tissue sections through complex laboratory procedures, the system uses neural networks to transform OCT images into virtual stained images, substituting a mechanical/chemical process with an information processing approach.

Inventive Principle:
Principle #28Mechanics substitution (Replace mechanical system)

2Measurement precision

If OCT imaging is used, then non-invasive high-resolution imaging is achieved, but dermatologist familiarity and diagnostic comfort decrease

Engineering Contradiction:
Improveimaging resolutionVSAvoiddiagnostic comfort
Core Design Contradiction:
Measurement precisionVSEase of operation

Solution Approach 1:

The system generates virtual stained images that replicate the appearance and diagnostic characteristics of traditional stained tissue sections. By creating synthetic images in the familiar stained image domain rather than requiring dermatologists to interpret OCT images directly, the system preserves high-resolution imaging capabilities while restoring diagnostic comfort through visual familiarity.

Inventive Principle:
Principle #26Copying

Solution Approach 2:

The deep learning model acts as an intermediary that translates OCT images into virtual stained images. This intermediary transformation bridges the gap between the advanced OCT imaging modality and the dermatologists' existing expertise in stained image interpretation, allowing them to maintain their diagnostic workflow while benefiting from non-invasive high-resolution imaging.

Inventive Principle:
Principle #24Intermediary (Mediator)

Data Source

PatentUS20250315945A1System and method for converting skin tissue images based on deep learning
Publication Date: 2025.10.09 NAT TAIWAN UNIV
  • US20250315945A1 patent drawing
  • US20250315945A1 patent drawing
  • US20250315945A1 patent drawing

AI summary

A system and a method for transforming skin tissue images based on deep learning are provided. The system includes a database, a processing circuit, and a first deep generative model. The database is configured to store an optical coherence tomography (OCT) image set and a stained image set of skin tissue. The processing circuit is coupled to the database. The first deep generative model is established by the processing circuit executing a deep learning process to learn a first mapping relationship from the OCT image set to the stained image set, and the first deep generative model is configured to convert a target OCT image into a virtual stained image.