Deer Antler MIC-1 Stem Cell Line for Tissue Regeneration

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Solution Overview

Problem

Current methods for reconstructing cartilaginous tissues face challenges such as long procedure times, post-surgical discomfort, limited availability of suitable materials, immune reactions, and ethical concerns with human stem cells, particularly in using embryonic tissue and xenogenic implants.

Innovation Solution

A stable stem cell line, MIC-1, derived from deer antlers, which exhibits high proliferation potential and low immune response, allowing for the reconstruction of connective tissue lesions with minimal immune rejection and ethical considerations, suitable for xenogenic implants.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Productivity

If human embryonic stem cells are used for tissue regeneration, then high proliferation potential is achieved, but ethical problems and risk of viral diseases/tumors increase

Engineering Contradiction:

Improveproliferation potentialVSAvoidethical problems and viral disease risk

Core Design Contradiction:

ProductivityVSObject-affected harmful factors

Solution Approach 1:

The invention segments the stem cell source from human embryonic tissue to deer antler tissue, separating the beneficial proliferation potential from the harmful ethical and safety concerns associated with human embryonic cells

Inventive Principle:

Principle #1Segmentation

Solution Approach 2:

Deer antler stem cells serve as an intermediary solution that provides the desired regenerative capability without directly involving human embryonic tissue, thus mediating between the need for high proliferation and the avoidance of ethical/viral risks

Inventive Principle:

Principle #24Intermediary (Mediator)

2Quantity of substance

If xenogenic implants are used for tissue reconstruction, then immune reaction occurs, but availability of suitable material increases

Engineering Contradiction:

Improveavailability of reconstructive materialVSAvoidimmune reaction

Core Design Contradiction:

Quantity of substanceVSObject-affected harmful factors

Solution Approach 1:

The invention changes the species parameter from human to deer, selecting deer antler stem cells that exhibit lower immunogenicity while maintaining high regenerative capacity, thus resolving the contradiction between material availability and immune compatibility

Inventive Principle:

Principle #35Parameter changes

3Reliability

If rib cartilage is harvested for reconstruction, then autologous material is obtained, but procedure time increases and post-surgical discomfort increases

Engineering Contradiction:

Improveautologous compatibilityVSAvoidprocedure time

Core Design Contradiction:

ReliabilityVSLoss of time

Solution Approach 1:

The invention applies preliminary action by pre-culturing stem cells from deer antlers before implantation, allowing the reconstructive material to be prepared in advance with high cell viability, thus reducing actual surgical procedure time while maintaining autologous-like compatibility

Inventive Principle:

Principle #10Preliminary action

Solution Approach 2:

The invention creates a copy of the desired regenerative effect by using deer antler stem cells that can be cultured ex vivo to produce large numbers of viable cells, replicating the benefits of autologous tissue without the time-consuming harvest procedure

Inventive Principle:

Principle #26Copying

Data Source

PatentEP2144639B1New stem cell line and its application

Publication Date: 2012.08.22 STEM CELLS SPIN SA

Figure 1a~1b

AI summary

New lines of stem cells from the growing antlers of deer (Cervidae) and the application of said cells in the reconstruction of connective tissue, preferentially bone, cartilage or adipose tissue, in humans and animals; as well as a method of culturing them and the application of tissues from growing deer antlers in the production of the MIC-1 stable stem cell line.