Defensin Concentration for Stem Cell Recruitment
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Solution Overview
Problem
Current cosmetic compositions using defensins for skin treatments often require high concentrations that may be allergenic and costly, and there is a need for effective topical formulations for healthy skin to reduce the appearance of aging without inhibiting microbial growth.
Innovation Solution
Development of topical cosmetic formulations containing defensins at sub-antimicrobially effective concentrations, specifically between 0.01 and 100 ng/ml, to recruit LGR6+ stem cells, reduce wrinkle depth, pore size, and improve skin brightness, using alpha-defensin 5 and beta-defensin 3, potentially encapsulated in liposomes with protein carriers like albumin.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If high concentrations of defensins are used in cosmetic formulations, then antimicrobial effectiveness is improved, but allergenicity and cost increase
Solution Approach 1:
The patent changes the concentration parameter of defensins from high (antimicrobial levels) to low (sub-antimicrobial levels). By adjusting this parameter, the formulation achieves cosmetic benefits for healthy skin without triggering allergic responses or incurring high costs associated with antimicrobial concentrations.
Solution Approach 2:
The patent applies different concentrations of defensins for different purposes: sub-antimicrobial concentrations (0.01-100 ng/ml) for cosmetic applications on healthy skin, and higher antimicrobial concentrations only when microbial inhibition is specifically needed. This localized quality approach optimizes both safety and effectiveness.
2Reliability
If high concentrations of defensins are used in cosmetic formulations, then antimicrobial effectiveness is improved, but cost increases
Solution Approach 1:
The patent changes the concentration parameter of defensins from high (antimicrobial levels) to low (sub-antimicrobial levels). By adjusting this parameter, the formulation achieves cosmetic benefits for healthy skin without incurring high costs associated with antimicrobial concentrations.
3Object-affected harmful factors
If sub-antimicrobial concentrations of defensins are used, then allergenicity and cost are reduced, but antimicrobial effectiveness is lost
Solution Approach 1:
The patent applies different concentrations of defensins for different purposes: sub-antimicrobial concentrations (0.01-100 ng/ml) for cosmetic applications on healthy skin, and higher antimicrobial concentrations only when microbial inhibition is specifically needed. This localized quality approach optimizes both safety and effectiveness.
4Reliability
If high concentrations of defensins are used, then wound healing is improved, but the formulation becomes more allergenic
Solution Approach 1:
The patent changes the concentration parameter of defensins from high (antimicrobial levels) to low (sub-antimicrobial levels). By adjusting this parameter, the formulation achieves cosmetic benefits for healthy skin without triggering allergic responses or incurring high costs associated with antimicrobial concentrations.
Data Source
AI summary
The inventive subject is directed towards ready-to-use topical cosmetic formulations that include at least one defensin present in sub-antimicrobially effective concentrations. Surprisingly, even at such low concentrations, defensins recruit LGR6+ stem cells from hair follicles to the interfollicular space. Including defensins in the inventive topical cosmetic formulations may reduce one or more of wrinkle depth, wrinkle length, wrinkle width, pore size, irregularity in texture of a skin surface, oiliness, brown spots, and red spots in non-injured skin, thus reducing apparent age.