Defined-Structure Ganoderma Polysaccharide to Mitigate Chemotherapy Toxicity
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Current treatments for advanced cancer patients with chemotherapy-induced toxic side effects and limited life expectancy do not effectively address tumor growth, side effects, and cancer cell proliferation, lacking broad-spectrum efficacy against cancers like lung and liver cancer.
Innovation Solution
A polysaccharide compound extracted from Ganoderma lucidum with a defined molecular structure (C30H50O25)n, obtained through high-temperature and high-pressure extraction, is combined with chemotherapy drugs to reduce side effects and enhance antitumor activity, stabilizing tumor size and preventing cancer cell formation.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If chemotherapy drugs are used to treat advanced cancer, then tumor size may be reduced, but toxic side effects are induced on the human body
Solution Approach 1:
The polysaccharide compound acts as a protective intermediary substance that mitigates the harmful effects of chemotherapy drugs on normal cells while preserving their antitumor activity. The compound is administered alongside chemotherapy drugs to reduce toxic side effects on the human body.
Solution Approach 2:
The invention changes the chemical parameters of the treatment regimen by introducing a polysaccharide compound with specific molecular structure (C30H50O25)n that modifies the overall therapeutic profile, reducing toxicity without compromising efficacy.
2Ease of manufacture
If conventional extraction methods are used for Ganoderma lucidum, then extraction process is simple, but the molecular structure and activity of polysaccharides are not well preserved
Solution Approach 1:
The invention applies high-temperature (100-200°C) and high-pressure extraction parameters to obtain polysaccharides with preserved molecular structure and enhanced activity, representing a significant departure from conventional low-temperature extraction methods.
Solution Approach 2:
The high-temperature high-pressure extraction method serves multiple functions: it extracts polysaccharides effectively, preserves their molecular structure, and potentially enhances their biological activity, making the process universally beneficial for obtaining high-quality Ganoderma lucidum polysaccharides.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The polysaccharide compound significantly alleviates chemotherapy side effects, stabilizes tumors, and demonstrates broad-spectrum antitumor activity against lung and liver cancer, enhancing patient quality of life and survival.
Implementation Method 1
placing the crushed Ganoderma lucidum powder in a sealed container mixed with water, heating under high temperature and pressure to fully dissolve the Ganoderma lucidum powder with the water into a medicinal juice solution
Implementation Method 2
using membrane concentration technology to separate the medicinal juice solution to obtain a concentrated solution with an active ingredient
Implementation Method 3
followed by multiple column chromatography separations to obtain the Ganoderma lucidum polysaccharide GLP-2 with the active ingredient
Data Source
AI summary
This invention pertains to the field of plant extraction and separation technology, and provides a polysaccharide compound with a defined molecular structure that possesses antitumor efficacy. The polysaccharide compound is intended for the treatment of advanced cancer patients (those who are no longer candidates for surgery, have a life expectancy of only three to six months, and are still eligible for chemotherapy). The molecular formula is: (C30H50O25)n. The active ingredient, polysaccharide, is obtained through the extraction of effective components from Ganoderma lucidum under high temperature and high pressure. The polysaccharide with this active ingredient, characterized by its water solubility, is readily absorbed by the human body, offers antitumor effects, and has proven efficacy in the prevention of tumor development in humans.