Elastically Deformable Biological Liquid Containment Units

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Solution Overview

Problem

Existing devices for filling containment units of biological liquids are complex, time-consuming, limited to flexible units, and inefficient in handling large numbers, unable to fill semi-rigid units due to air obstruction and waste of biological liquid.

Innovation Solution

A device with a continuous filling channel, hydrophobic air filtering, and elastically deformable containment units that allow air expulsion and filling of flexible, semi-rigid, or rigid units in series, enabling efficient and flexible filling of multiple units.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If vacuum aspiration is used to empty flexible containment units, then air is removed from the units, but the process is time-consuming and requires repeated operations

Engineering Contradiction:
Improveair removal completenessVSAvoidpreparation time
Core Design Contradiction:
ReliabilityVSLoss of time

Solution Approach 1:

The containment units are pre-deformed to a compressed state before filling, creating an air expulsion pathway and reducing internal volume. This preliminary deformation eliminates the need for repeated vacuum aspiration operations, as air is automatically expelled during the filling process itself, significantly reducing preparation time while ensuring complete air removal.

Inventive Principle:
Principle #10Preliminary action

Solution Approach 2:

Instead of using vacuum to pull air out of the units, the invention inverts the approach by using positive pressure from the filling liquid to push air out through the deformation pathway. The liquid flow itself becomes the driving force for air expulsion, reversing the traditional vacuum aspiration method and eliminating time-consuming repeated operations.

Inventive Principle:
Principle #13The other way round (Inversion)

2Productivity

If connecting elements are enlarged to handle more containment units, then more units can be filled, but biological liquid waste increases

Engineering Contradiction:
Improvenumber of units filledVSAvoidbiological liquid waste
Core Design Contradiction:
ProductivityVSLoss of substance

Solution Approach 1:

The system segments the filling process into individual unit operations, with each containment unit being filled separately through the same connecting elements. The connecting elements are designed to interface with multiple units in sequence without requiring enlargement, as each unit is filled independently. This segmentation allows high productivity while maintaining minimal liquid waste, as the connecting elements remain the same size regardless of the number of units processed.

Inventive Principle:
Principle #1Segmentation

Solution Approach 2:

The filling process operates continuously with the syringe plunger moving in one direction to fill multiple units sequentially. The connecting elements facilitate this continuous action without requiring enlargement or complex configurations, allowing the system to maintain efficient liquid transfer with minimal waste while increasing the number of units that can be filled in a single operation.

Inventive Principle:
Principle #20Continuity of useful action

3Reliability

If vacuum aspiration is used to fill containment units, then filling can be performed, but air bubbles obstruct the liquid flow and prevent complete filling

Engineering Contradiction:
Improvefilling completenessVSAvoidbiological liquid waste
Core Design Contradiction:
ReliabilityVSLoss of substance

Solution Approach 1:

The containment units are pre-deformed to create an air expulsion pathway before filling begins. This preliminary action positions the unit walls to facilitate air escape during filling, ensuring that air bubbles do not obstruct the liquid flow. As a result, complete filling is achieved without waste, as the deformation pathway allows air to be pushed out continuously during the filling process.

Inventive Principle:
Principle #10Preliminary action

Solution Approach 2:

The invention inverts the traditional vacuum filling approach by using positive pressure from the syringe to push liquid into the units. This positive pressure flow, combined with the pre-created deformation pathway, naturally expels air bubbles during filling. The inversion eliminates air obstruction problems and prevents liquid waste, as the filling liquid itself drives air expulsion rather than relying on vacuum aspiration.

Inventive Principle:
Principle #13The other way round (Inversion)

4Reliability

If soft flexible containment units are used, then they can be emptied of air by vacuum, but they cannot provide controlled dispensing of biological liquid

Engineering Contradiction:
Improveair removal capabilityVSAvoiddispensing control
Core Design Contradiction:
ReliabilityVSEase of operation

Solution Approach 1:

The containment units are pre-deformed to a compressed state that creates an air expulsion pathway. This preliminary deformation allows the units to be easily filled and air-free, while the same deformation mechanism enables controlled dispensing. The elastic memory of the deformed walls provides a one-way valve effect that allows filling but controls dispensing, combining both advantages in a single structural feature.

Inventive Principle:
Principle #10Preliminary action

Solution Approach 2:

The containment units utilize dynamic deformation of their walls to provide different functions at different stages. During filling, the deformed walls facilitate air expulsion and liquid entry. During dispensing, the elastic recovery of the deformed walls creates a one-way valve effect that controls liquid flow. This dynamic structural change allows the same unit to provide both air removal capability and dispensing control without requiring different unit types.

Inventive Principle:
Principle #15Dynamics

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The method simplifies the preparation of biological liquid containment units, reduces preparation time, and allows filling of any type of unit, including semi-rigid ones, by automatically expelling air and minimizing liquid waste, enhancing flexibility and efficiency.

Implementation Method 1

injecting a biological fluid along said channel (3) through said inlet opening (3a) so as to push towards outside the air contained inside said containment chambers (5) through the outlet gap (3b)

Methodology Applied
Scientific EffectPressure differential: Pressure Gradient

Implementation Method 2

a hydrophobic air filtering device (6) associated with said body (2) in correspondence to said outlet gap (3b)

Methodology Applied
Scientific EffectHydrophobic filtering: Hydrophobe

Implementation Method 3

containment units (4) are bulbous members each having opposing elastically deformable sides that define the respective containment chambers therebetween, and wherein after deformation the sides return to a convex non-deformed idle configuration

Methodology Applied
Scientific EffectElastic recovery: Elasticity

Data Source

PatentUS10745153B2Method for the preparation of containment units of biological liquids
Publication Date: 2020.08.18 BIOMED DEVICE
  • US10745153B2 patent drawing
  • US10745153B2 patent drawing

AI summary

The method for the preparation of containment units of biological liquids, comprises the following stages of: furnishing a device (1) comprising a main body (2) which defines at least a continuous filling channel (3), having at least an inlet gap (3a) of a biological liquid and at least an air outlet gap (3b), a plurality of containment units (4) arranged in succession to one another so as to communicate with each other and defining respective containment chambers (5) positioned along the filling channel (3) and placed in between the inlet gap (3a) and the outlet gap (3b), a hydrophobic air filtering device (6) associated with the body (2) in correspondence to the outlet gap (3b), wherein the containment units (4) are bulbous members each having opposing elastically deformable sides that define the respective containment chambers therebetween, and wherein after deformation the sides return to a convex non-deformed idle configuration in which the sides are at a non-zero distance from one another;injecting a biological fluid along the channel (3) through the inlet opening (3a) so as to push towards outside the air contained inside the containment chambers (5) through the outlet gap (3b) and to gradually filling the containment chambers (5) which it crosses;closing and isolating the containment units (4) the one from the other.