Delayed-Release Analgesic Formulation for Urination Frequency
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Solution Overview
Problem
Individuals experience frequent urination urges even when the bladder is less than 100% full, leading to disruptions in daily activities and potentially associated with medical conditions, necessitating a solution to inhibit muscle contraction and delay the urge to urinate until the bladder reaches 100% capacity.
Innovation Solution
A pharmaceutical composition comprising acetaminophen as a delayed-release analgesic agent, potentially combined with other analgesics or antimuscarinic agents, administered in specific dosages and timing to reduce the frequency of urination, including a diuretic component to manage nocturia, utilizing enteric coatings for controlled release.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Duration of action of moving object
If immediate-release analgesic agents are used, then pain relief is achieved quickly, but the urge to urinate occurs too frequently disrupting sleep and daily activities
Solution Approach 1:
The delayed-release formulation is designed to release the analgesic agent at a predetermined time (typically during nighttime sleep period), allowing the medication to be taken before bed and release its active ingredient when needed to suppress urination urges during sleep, thereby preventing interruptions without requiring immediate action
Solution Approach 2:
The invention changes the release parameter of the analgesic agent from immediate to delayed timing through enteric coating technology, transforming the temporal profile of drug delivery to match the physiological need for reduced urination frequency during specific periods (nighttime)
2Duration of action of moving object
If higher doses of analgesic agents are administered to extend duration, then urination frequency is reduced, but side effects and toxicity increase
Solution Approach 1:
The delayed-release formulation provides periodic action by releasing the analgesic agent at specific predetermined times (e.g., during nighttime period), rather than maintaining continuous high-level presence in the system, thus achieving the desired duration of effect while limiting cumulative exposure and side effects
Solution Approach 2:
The invention replaces the mechanical approach of increasing dose magnitude with a temporal approach using delayed-release technology, substituting the need for higher doses with strategically timed lower doses that achieve the same therapeutic effect with reduced toxicity
3Reliability
If multiple medications are combined to treat urination frequency, then therapeutic effect is enhanced, but device complexity and administration difficulty increase
Solution Approach 1:
The invention merges multiple therapeutic agents (analgesic and antimuscarinic) into a single delayed-release pharmaceutical composition, combining their effects to enhance therapeutic reliability while simplifying administration to a single pill rather than multiple separate medications
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition effectively reduces the frequency of urination by delaying the urge to void until the bladder is fully filled, improving sleep quality and daily activity by minimizing nocturnal awakenings due to urination needs.
Implementation Method 1
wherein said pharmaceutical composition is in a delayed-release formulation that comprises an enteric coating
Data Source
Figure 1A~1B
AI summary
Methods and compositions for reducing the frequency of urination are disclosed. One method comprises administering to a subject in need thereof an effective amount of a pharmaceutical composition comprising an analgesic agent formulated in a delayed-release formulation. Another method comprises administering to a subject in need thereof an effective amount of a pharmaceutical composition comprising multiple active ingredients. Yet another method comprises administering to a subject in need thereof an effective amount of a diuretic followed with another administration of an pharmaceutical composition comprising an analgesic agent.