Delivery Catheter Targeted Tissue Denervation for Symptom Relief
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Solution Overview
Problem
Current treatments for hypertension, diabetes, obesity, and other conditions are suboptimal, with limited effectiveness in controlling symptoms and managing associated health issues such as urinary obstruction, respiratory diseases, and metabolic disorders.
Innovation Solution
A delivery catheter system that enables the targeted delivery of chemical formulations and energy to specific tissues within the body, using radiofrequency, cryoablation, microwave, or ultrasound energies to denervate or ablate tissues, thereby reducing blood pressure, glucose levels, body weight, and fat accumulation, among other symptoms.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If current treatments for hypertension, diabetes, obesity are used, then treatment is provided, but effectiveness in controlling symptoms is limited
Solution Approach 1:
The treatment system is segmented into multiple independent functional modules within the catheter, including separate delivery channels for chemical formulations and energy delivery components for ablation. This allows each module to be optimized independently while working together to achieve comprehensive treatment effectiveness for multiple conditions simultaneously.
Solution Approach 2:
The catheter system is designed with multi-functionality to treat multiple conditions (hypertension, diabetes, obesity) through a single device. It can deliver different chemical formulations through separate channels and provide energy delivery for ablation, enabling one system to address various symptoms and diseases that previously required multiple separate treatments.
2Manufacturing precision
If targeted delivery of chemical formulations and energy is implemented, then treatment precision is improved, but device complexity increases
Solution Approach 1:
The catheter employs a nested structure where multiple delivery channels are positioned concentrically within the catheter body. The chemical formulation channels are nested within the catheter shaft, and energy delivery components are integrated within the same structure. This nesting approach allows precise targeting of tissues while maintaining a compact, manageable device architecture.
Solution Approach 2:
The catheter system introduces a centering balloon as an intermediary component that facilitates precise positioning of the catheter tip at the target tissue location. The balloon expands to provide a stable platform and visual/fluoroscopic marker, enabling accurate delivery of chemical formulations and energy to the intended tissue without requiring complex steering mechanisms.
3Productivity
If multiple body lumens are treated in one procedure, then treatment efficiency is improved, but procedural complexity increases
Solution Approach 1:
The catheter system is designed with universal applicability to treat multiple body lumens including renal arteries, hepatic arteries, and other vascular beds through a single device platform. The same catheter design can be adapted for different anatomical locations by delivering appropriate chemical formulations and energy levels, eliminating the need for multiple specialized devices and simplifying the overall procedural workflow.
Solution Approach 2:
The system enables treatment of multiple body lumens by adjusting delivery parameters such as chemical formulation concentration, flow rate, and energy delivery intensity rather than changing the fundamental device structure. These parameter modifications allow the same catheter to effectively treat different tissues and conditions, improving treatment efficiency without proportionally increasing procedural complexity.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The system effectively relieves symptoms by reducing blood pressure, glucose levels, body weight, and fat accumulation, improving treatment safety and efficacy by directly addressing the underlying tissues responsible for these conditions.
Implementation Method 1
using radiofrequency, cryoablation, microwave, or ultrasound energies to denervate or ablate tissues
Implementation Method 2
using radiofrequency, cryoablation, microwave, or ultrasound energies to denervate or ablate tissues
Implementation Method 3
using radiofrequency, cryoablation, microwave, or ultrasound energies to denervate or ablate tissues
Implementation Method 4
using radiofrequency, cryoablation, microwave, or ultrasound energies to denervate or ablate tissues
Data Source
AI summary
Embodiments of the present invention provide a device and a method for at least one disease by delivering an effective amount of energy and/or formulation to tissue on or near to a body lumen wall. The formulation can include at least one of a gas, a vapor, a liquid, a solution, an emulsion, a suspension of one or more ingredients, or a combination thereof. The amounts of the formulation and/or energy delivered can be effective to injure or damage tissue, nerves, and/or nerve endings to relieve disease symptoms.