Demineralized Bone Matrix Sheet With Ionic Crosslinking
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Demineralized bone matrix (DBM) materials used in medical implants are susceptible to disruption by incompatible materials or techniques, requiring a formulation that maintains osteoinductivity while providing physical integrity and manufacturability without excessive cost or equipment burdens.
Innovation Solution
A sheet-form DBM device with a resilient, porous structure comprising particulate collagen and DBM materials retained by an ionically-crosslinked polysaccharide gel, offering a 3D stable scaffold for bone growth and improved handling properties.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If demineralized bone matrix is incorporated into implant formulations, then osteoinductivity is improved, but physical integrity and handling properties deteriorate
Solution Approach 1:
The patent creates a composite material combining demineralized bone matrix particles with a collagen sponge matrix. The collagen sponge provides structural integrity and handling properties while the DBM particles maintain osteoinductivity. This composite structure allows both materials to contribute their beneficial properties without compromising each other.
Solution Approach 2:
The patent uses a collagen sponge as a flexible matrix that can be formed into sheet-like structures. This flexible matrix provides physical integrity and ease of handling while allowing the embedded DBM particles to maintain their osteoinductive properties. The collagen sponge acts as a protective scaffold that preserves DBM functionality.
2Strength
If traditional bone grafting techniques are used, then physical integrity is maintained, but osteoinductivity is reduced
Solution Approach 1:
The patent combines traditional collagen sponge materials with demineralized bone matrix particles to create a composite that maintains both physical integrity and osteoinductivity. The collagen sponge provides the structural framework while the DBM particles ensure bone formation capability, overcoming the limitations of traditional single-material approaches.
3Strength
If complex formulation techniques are used to retain DBM, then physical integrity is improved, but manufacturing complexity and cost increase
Solution Approach 1:
The patent merges the collagen sponge matrix with DBM particles in a simple admixture process. The collagen sponge is cut into small pieces and mixed with DBM particles, creating a homogeneous composite. This combining approach provides physical integrity while maintaining manufacturing simplicity and reducing costs.
Solution Approach 2:
The patent controls the size parameters of the collagen sponge pieces and the ratio of DBM particles to sponge material. By optimizing these parameters, the patent achieves adequate physical integrity without requiring complex formulation techniques or expensive equipment, thereby reducing manufacturing complexity.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The device effectively retains DBM osteoinductivity, enhances handling and implantation properties, and is manufacturable with reduced costs and equipment burdens, making it suitable for bone growth promotion in medical applications.
Implementation Method 1
The particulate solids are retained in the porous implant structure form by an ionically-crosslinked polysaccharide gel
Implementation Method 2
Particles of the particulate collagen material are individually chemically or otherwise crosslinked
Data Source
AI summary
Described are medical implant devices that include particulate collagen and particulate demineralized bone matrix. These and potentially other materials are held together in a three-dimensionally stable structure such as a porous, resilient sheet, by an ionically-crosslinked polysaccharide gel. Also described are methods for making and using such medical devices.