Dendrobium Officinale Extraction for Hypertension Treatment
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Solution Overview
Problem
Current treatments for hypertension, both Western and traditional Chinese medicine, face challenges such as inadequate antihypertensive effects, side effects, and inefficiencies in drug extraction methods, which limit their effectiveness and practical application in clinical settings.
Innovation Solution
The use of Dendrobium officinale in a method involving grinding into a powder and employing a combination of alcohol and water extraction followed by pharmaceutical processing to create tablets, granules, or capsules, which enhances the extraction and utilization of active ingredients, leading to improved antihypertensive effects comparable to Western medications like amlodipine.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If traditional water extraction method is used for Dendrobium officinale, then the extraction process is simple, but the antihypertensive effect is insufficient and slow
Solution Approach 1:
The extraction process is divided into multiple sequential steps: first alcohol extraction to obtain alcohol extract, then water extraction of the residue to obtain water extract. This segmentation allows different components to be extracted selectively, improving the overall antihypertensive effect while maintaining a manageable process complexity
Solution Approach 2:
The patent changes the extraction parameters by using different solvents (alcohol and water) in sequence, and controlling extraction temperatures (60°C for alcohol extraction, 100°C for water extraction). These parameter changes enhance the extraction efficiency and antihypertensive effect without making the process overly complex
2Speed
If Western medicine is used for hypertension treatment, then blood pressure reduction is fast, but side effects increase and long-term efficacy decreases
Solution Approach 1:
The patent optimizes extraction parameters including temperature (60°C for alcohol, 100°C for water), solvent ratios (5 times crude drug amount for alcohol, 30 times for water), and extraction time (24 hours for alcohol, 2 hours for water). These parameter optimizations enable the traditional medicine to achieve fast blood pressure reduction comparable to Western medicine while maintaining fewer side effects
Solution Approach 2:
The patent combines alcohol extract and water extract to create a composite preparation that contains multiple active ingredients from Dendrobium officinale. This composite approach provides both rapid blood pressure reduction and long-term efficacy without the harmful side effects associated with single-component Western medications
3Stability of the object's composition
If traditional Chinese medicine is used for hypertension, then curative effect is stable and lasting, but blood pressure reduction speed is slow
Solution Approach 1:
The patent segments the extraction into alcohol and water phases, where alcohol extraction targets compounds for rapid blood pressure reduction while water extraction targets compounds for stable long-term curative effect. This segmentation resolves the contradiction between speed and stability
Solution Approach 2:
The alcohol extraction is performed first to obtain compounds that provide rapid initial blood pressure reduction, preparing the system for the subsequent water extraction that provides stable long-term effects. This preliminary action sequence addresses both speed and stability requirements
4Reliability
If multiple antihypertensive prescriptions are used, then target blood pressure can be reached, but drug interactions occur and treatment complexity increases
Solution Approach 1:
The patent merges multiple extraction methods (alcohol and water extraction) into a single integrated preparation process, combining the benefits of both extraction types into one medication. This reduces treatment complexity while maintaining effective blood pressure control
Solution Approach 2:
The final preparation is a composite containing both alcohol-extracted and water-extracted components from Dendrobium officinale. This single composite medication provides comprehensive antihypertensive effects without the drug interactions and complexity of multiple separate prescriptions
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This method significantly improves the short-acting and long-acting antihypertensive effects of Dendrobium officinale, achieving a stable 24-hour blood pressure reduction similar to Western medications with fewer side effects and greater stability, making it a more effective treatment for hypertension.
Implementation Method 1
the alcohol extraction: add 75% ethanol with 5 times the amount of crude drug is extracted at 60° C. for 24 hours
Implementation Method 2
the water extraction is two gradient heating water extraction; wherein the extraction temperature is controlled to be 100° C. in the first water extraction, and the extraction temperature is controlled to be 121° C. in the second water extraction
Implementation Method 3
the water extraction is two gradient heating water extraction; wherein the extraction temperature is controlled to be 100° C. in the first water extraction, and the extraction temperature is controlled to be 121° C. in the second water extraction
Data Source
AI summary
An application method of Dendrobium candidum in preparing a medicine for treating hypertension, includes: separately adding an adjuvant, according to a conventional medicine processing method, into Dendrobium candidum powder, or an extracting solution of Dendrobium candidum powder obtained by alcohol and water extraction, or a mixture of Dendrobium candidum powder and the extracting solution obtained by alcohol and water extraction, and preparing same as traditional Chinese medicine tablets, granules, suspended granules, pills, powder, or capsules, thereby obtaining a medicine for treating hypertension.