Dense Collagen–Hydroxyapatite Compositions for Injectable Bone Repair

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Solution Overview

Problem

Existing injectable and implantable compositions for mineralized tissue repair and regeneration, such as bone, lack biomimetic properties, mechanical strength, and are not easily injectable, often requiring chemical crosslinking that can cause inflammation and poor biological response.

Innovation Solution

A composition comprising dense collagen microparticles (>90% collagen) combined with biomimetic hydroxyapatite or its precursors and a physiologically compatible aqueous solvent, allowing for injectable and implantable mineralized tissue substitutes that mimic bone ultrastructure and promote host cell colonization without inflammation.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Ease of operation

If low concentrated collagen is used to form injectable microspheres, then injectability is improved, but mechanical strength and structural stability deteriorate due to fragility requiring chemical crosslinking

Engineering Contradiction:

ImproveinjectabilityVSAvoidmechanical strength

Core Design Contradiction:

Ease of operationVSStrength

Solution Approach 1:

The patent combines high concentrated collagen with hydroxyapatite to form a composite material that achieves both injectability and mechanical strength. The hydroxyapatite particles act as a reinforcing phase that provides structural stability to the collagen matrix, eliminating the need for chemical crosslinking while maintaining structural integrity during injection and implantation.

Inventive Principle:

Principle #40Composite materials

Solution Approach 2:

The patent changes the concentration parameter of collagen from low (in existing microspheres) to high (in the new composition), enabling the formation of a structurally stable matrix that can be injected and implanted without chemical crosslinking. The high collagen concentration allows the material to maintain its shape and mechanical properties while remaining injectable.

Inventive Principle:

Principle #35Parameter changes

2Stability of the object's composition

If chemical crosslinking is applied to stabilize low concentrated collagen microspheres, then structural stability is improved, but biological response deteriorates due to inflammation from residual crosslinking agents

Engineering Contradiction:

Improvestructural stabilityVSAvoidinflammation

Core Design Contradiction:

Stability of the object's compositionVSObject-affected harmful factors

Solution Approach 1:

The patent extracts and eliminates the need for chemical crosslinking agents by using high concentrated collagen combined with hydroxyapatite. The high collagen concentration and hydroxyapatite reinforcement provide structural stability through physical rather than chemical means, removing the source of inflammation and improving biocompatibility.

Inventive Principle:

Principle #2Taking out (Extraction)

3Ease of operation

If low concentrated collagen is used for injectability, then ease of injection is improved, but ability to form bone-like 3D architecture deteriorates because collagen self-assembly threshold is not reached

Engineering Contradiction:

Improveease of injectionVSAvoid3D architecture

Core Design Contradiction:

Ease of operationVSShape

Solution Approach 1:

The patent changes the collagen concentration parameter from low to high, exceeding the self-assembly threshold required for forming bone-like 3D architecture. The high concentrated collagen naturally assembles into fibrillar structures that mimic native bone extracellular matrix, while the material remains injectable due to its formulation and the reinforcing effect of hydroxyapatite.

Inventive Principle:

Principle #35Parameter changes

4Shape

If high concentrated collagen is used to form bone-like ultrastructure, then biomimetic properties are improved, but injectability deteriorates due to high viscosity

Engineering Contradiction:

Improvebone-like ultrastructureVSAvoidinjectability

Core Design Contradiction:

ShapeVSEase of operation

Solution Approach 1:

The patent creates a composite material combining high concentrated collagen with hydroxyapatite particles. The hydroxyapatite acts as a space-filling reinforcement that allows the high concentrated collagen to maintain its bone-like ultrastructure while reducing the overall viscosity and improving injectability of the composition.

Inventive Principle:

Principle #40Composite materials

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The composition provides biocompatible, biomimetic mineralized tissue substitutes with improved mechanical properties and adhesion, facilitating rapid tissue regeneration and bone repair without the need for chemical crosslinking.

Implementation Method 1

the 3D organization of highly concentrated collagen materials appears as a sine qua non condition to mimic the ultrastructure of biological tissues

Methodology Applied

Scientific EffectSelf-assembly: Self-Assembly

Implementation Method 2

the mineralization of highly concentrated collagen matrices promotes both the formation of biomimetic hydroxyapatite nanoplatelets and their co-alignment with collagen fibrils

Methodology Applied

Scientific EffectCo-alignment:

Data Source

PatentUS20250205393A1Compositions for mineralized tissues repair and regeneration

Publication Date: 2025.06.26 SORBONNE UNIVERSITE

AI summary

The present disclosure relates to injectable or implantable compositions that are able to mimic different types of mineralized biological tissues and their uses in mineralized tissues repair and regeneration.