DENSE MRI Cardiac Strain Analysis Using Meshfree Radial Point Interpolation
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Solution Overview
Problem
Current Magnetic Resonance Imaging (MRI) techniques, such as tagged MRI, have low spatiotemporal resolution and lengthy post-processing times, leading to imprecise data and increased operation duration for cardiac strain analysis.
Innovation Solution
The use of a Displacement ENcoding with Stimulated Echoes (DENSE) sequence combined with a meshfree numerical analysis technique, specifically radial point interpolation method (RPIM), for acquiring and processing MRI data to enhance spatiotemporal resolution and reduce processing time for three-dimensional cardiac strain analysis.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If tagged MRI is used for cardiac strain analysis, then regional myocardial function can be visualized, but the spatiotemporal resolution is low and processing time is long
Solution Approach 1:
The patent replaces traditional mechanical/image-based tag tracking with magnetic phase encoding. The DENSE technique encodes displacement information directly into the phase of MRI signals, allowing displacement and strain calculation through phase differencing rather than visual tag tracking. This substitution of measurement mechanism enables both high spatiotemporal resolution and rapid processing.
Solution Approach 2:
The patent changes the fundamental parameter used for motion tracking from spatial tag patterns to phase encoding values. By encoding displacement in the phase domain rather than spatial domain, the system achieves higher precision measurement and faster computation. The phase information provides direct quantitative displacement data without requiring post-processing image analysis.
2Measurement precision
If tagged MRI with post-processing algorithms is used, then strain information can be obtained, but the data precision is imprecise and operation duration increases
Solution Approach 1:
The patent replaces complex post-processing algorithms that analyze tag motion with direct phase-based displacement measurement. The DENSE technique encodes displacement information in the phase of stimulated echoes, allowing strain calculation through simple phase differencing and numerical differentiation, eliminating the need for lengthy image processing while improving measurement precision.
Solution Approach 2:
The patent performs displacement encoding during the MRI signal acquisition itself rather than requiring separate post-processing steps. The phase information is encoded into the signals during the imaging process, so displacement and strain data are readily available immediately after reconstruction, significantly reducing operation duration.
Data Source
AI summary
A method for rapid computation of three-dimensional displacement and Lagrange strain in a high resolution filed of phase data obtained with Displacement Encoding with Stimulated Echoes (DENSE) in magnetic resonance images of the myocardium. The method includes semi-automated segmentation of a region of a heart, phase unwrapping the images in three dimensions, and a custom radial point interpolation method (RPIM). The RPIM is a meshfree numerical analysis method that uses radial basis functions and polynomial functions to calculate the Lagrange strain of DENSE displacement data acquired from the myocardium.


