DENSE MRI Cardiac Strain Analysis Using Meshfree Radial Point Interpolation

Resolve Bottlenecks,
Find Innovative Solutions
Generate Solutions

Solution Overview

Problem

Current Magnetic Resonance Imaging (MRI) techniques, such as tagged MRI, have low spatiotemporal resolution and lengthy post-processing times, leading to imprecise data and increased operation duration for cardiac strain analysis.

Innovation Solution

The use of a Displacement ENcoding with Stimulated Echoes (DENSE) sequence combined with a meshfree numerical analysis technique, specifically radial point interpolation method (RPIM), for acquiring and processing MRI data to enhance spatiotemporal resolution and reduce processing time for three-dimensional cardiac strain analysis.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Measurement precision

If tagged MRI is used for cardiac strain analysis, then regional myocardial function can be visualized, but the spatiotemporal resolution is low and processing time is long

Engineering Contradiction:
Improvespatiotemporal resolutionVSAvoidprocessing time
Core Design Contradiction:
Measurement precisionVSLoss of time

Solution Approach 1:

The patent replaces traditional mechanical/image-based tag tracking with magnetic phase encoding. The DENSE technique encodes displacement information directly into the phase of MRI signals, allowing displacement and strain calculation through phase differencing rather than visual tag tracking. This substitution of measurement mechanism enables both high spatiotemporal resolution and rapid processing.

Inventive Principle:
Principle #28Mechanics substitution (Replace mechanical system)

Solution Approach 2:

The patent changes the fundamental parameter used for motion tracking from spatial tag patterns to phase encoding values. By encoding displacement in the phase domain rather than spatial domain, the system achieves higher precision measurement and faster computation. The phase information provides direct quantitative displacement data without requiring post-processing image analysis.

Inventive Principle:
Principle #35Parameter changes

2Measurement precision

If tagged MRI with post-processing algorithms is used, then strain information can be obtained, but the data precision is imprecise and operation duration increases

Engineering Contradiction:
Improvestrain data precisionVSAvoidoperation duration
Core Design Contradiction:
Measurement precisionVSDuration of action of moving object

Solution Approach 1:

The patent replaces complex post-processing algorithms that analyze tag motion with direct phase-based displacement measurement. The DENSE technique encodes displacement information in the phase of stimulated echoes, allowing strain calculation through simple phase differencing and numerical differentiation, eliminating the need for lengthy image processing while improving measurement precision.

Inventive Principle:
Principle #28Mechanics substitution (Replace mechanical system)

Solution Approach 2:

The patent performs displacement encoding during the MRI signal acquisition itself rather than requiring separate post-processing steps. The phase information is encoded into the signals during the imaging process, so displacement and strain data are readily available immediately after reconstruction, significantly reducing operation duration.

Inventive Principle:
Principle #10Preliminary action

Data Source

PatentUS10278583B2Systems and methods for measuring cardiac strain
Publication Date: 2019.05.07 WASHINGTON UNIV IN SAINT LOUIS
  • US10278583B2 patent drawing
  • US10278583B2 patent drawing
  • US10278583B2 patent drawing

AI summary

A method for rapid computation of three-dimensional displacement and Lagrange strain in a high resolution filed of phase data obtained with Displacement Encoding with Stimulated Echoes (DENSE) in magnetic resonance images of the myocardium. The method includes semi-automated segmentation of a region of a heart, phase unwrapping the images in three dimensions, and a custom radial point interpolation method (RPIM). The RPIM is a meshfree numerical analysis method that uses radial basis functions and polynomial functions to calculate the Lagrange strain of DENSE displacement data acquired from the myocardium.