Density Gradient Liquid Production for Automated Particle Sizing
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Solution Overview
Problem
Existing methods for producing density gradient liquids in centrifugal sedimentation particle diameter distribution measurement devices are inefficient, requiring manual preparation of multiple sucrose solutions with different densities and pH levels for each sample, which is time-consuming and labor-intensive.
Innovation Solution
A density gradient liquid production apparatus that includes a first solution preparation unit and a second solution preparation unit, each mixing reference solutions with varying concentrations of agglomeration inhibiting components, and a mixed solution preparation unit to create a mixed solution with a target concentration, allowing for efficient production of multiple density gradient liquids with different concentrations of agglomeration inhibiting components.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Manufacturing precision
If manual preparation of multiple sucrose solutions with different densities and pH levels is performed for each sample, then the required pH and density adjustments can be achieved, but the process becomes time-consuming and labor-intensive
Solution Approach 1:
The invention divides the solution preparation into separate functional units: a first solution preparation unit that prepares solutions with different pH levels, and a second solution preparation unit that prepares solutions with different densities. This segmentation allows each unit to specialize in one parameter, improving both precision and efficiency.
Solution Approach 2:
The invention creates a multi-functional system where the first and second solution preparation units can independently prepare various solutions, and a mixing unit can combine them to create density gradient liquids with any desired pH and density combination. This universal approach eliminates the need for manual re-preparation for each sample.
2Manufacturing precision
If multiple sucrose solutions with different densities are prepared manually for each density gradient liquid, then the required density variations can be achieved, but the manual preparation becomes labor-intensive and inefficient
Solution Approach 1:
The system is designed to be self-serving by automatically preparing the required solutions through programmed operations. The first and second solution preparation units can autonomously prepare solutions with specified pH and density, and the mixing unit automatically combines them, eliminating manual intervention and simplifying operation.
Solution Approach 2:
The invention uses parameter changes by automatically adjusting pH and density parameters through controlled mixing of reference solutions. The system can change these parameters precisely by varying the mixing ratios of solutions with different properties, achieving the desired density gradient liquids without manual preparation.
3Reliability
If pH adjustment is performed manually for each sample type and particle diameter, then particle agglomeration can be prevented, but the process becomes time-consuming
Solution Approach 1:
The first solution preparation unit pre-preares multiple sucrose solutions with different pH levels before they are needed. This preliminary action allows the system to have ready-to-use solutions with various pH values, eliminating the need for time-consuming manual pH adjustment for each sample.
Solution Approach 2:
The system creates copies of reference solutions with different pH and density properties through automated mixing. Instead of manually adjusting pH for each sample, the system generates multiple copies of base solutions with predetermined pH values, which can then be quickly combined to create the required density gradient liquids.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables efficient production of multiple density gradient liquids with varying concentrations of agglomeration inhibiting components, reducing the need for manual preparation and enhancing the efficiency of the process.
Implementation Method 1
a first solution preparation unit (1) that prepares a first solution (31) with a predetermined target concentration and a first density by mixing a plurality of first reference solutions (11a, 11b) each of whose concentrations of an agglomeration inhibiting component that inhibits agglomeration of particles differs
Implementation Method 2
a second solution preparation unit (2) that prepares a second solution (32) with the predetermined target concentration and a second density that is different from the first density by mixing a plurality of second reference solutions (21a, 21b) each of whose concentrations of an agglomeration inhibiting component differs
Implementation Method 3
a mixed solution preparation unit (3) that creates a mixed solution with the target concentration by mixing the first solution and the second solution and supplies the created mixed solution to the measurement cell while varying a density of the mixed solution
Implementation Method 4
each particle contained in the measurement sample is separated by each of particle diameters in a measurement cell by injecting a measurement sample into a sucrose density gradient liquid produced in the measurement cell and rotating the density gradient liquid to apply a centrifugal force to the density gradient liquid
Data Source
AI summary
Provided is a density gradient liquid production apparatus for producing a density gradient liquid in a measurement cell for a centrifugal sedimentation type particle diameter distribution measurement device and comprises a first solution preparation unit that prepares a first solution with a predetermined target concentration and a first density by mixing a plurality of first reference solutions each of whose concentrations of an agglomeration inhibiting component that inhibits agglomeration of particles differs, and a second solution preparation unit that prepares a second solution with the predetermined target concentration and a second density that is different from the first density by mixing a plurality of second reference solutions each of whose concentrations of the agglomeration inhibiting component differs, and a mixed solution preparation unit that creates a mixed solution with the target concentration by mixing the first solution and the second solution and supplies the created mixed solution to the measurement cell while varying a density of the mixed solution.