Density-Modified Staining Composition for Ocular Tissue Targeting
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Solution Overview
Problem
Current staining compositions used in eye surgery face issues such as partial removal of dye during rinsing, unwanted staining of rinsing solutions, and diffusion of dye through ocular tissues, leading to reduced visibility and increased difficulty in distinguishing between tissues during surgery.
Innovation Solution
A staining composition comprising a vital dye and a density-increasing compound like polyethylene glycol (PEG) or small inert molecules, which enhances the density of the composition, allowing it to penetrate ocular tissues faster and remain localized, thereby reducing the risk of undesired staining and improving tissue differentiation.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Speed
If a staining composition is applied to ocular tissue and allowed to spread by gravity, then the dye can penetrate the tissue, but the dye may diffuse through the tissue and stain surrounding areas, reducing visibility
Solution Approach 1:
The patent changes the physical parameter of density by adding high molecular weight polymers (dextran, cellulose derivatives, starch, or proteins) to the staining composition. This increases the density of the composition, causing it to sink rapidly onto the ocular tissue and remain localized, preventing diffusion into surrounding areas while maintaining effective penetration of the target tissue.
Solution Approach 2:
The staining composition is formulated as a composite material combining a dye (such as trypan blue, trypan red, or brilliant cresyl blue) with a high molecular weight polymer matrix. This composite structure allows the dye to be delivered effectively to the tissue while the polymer provides density and localization, preventing unwanted spread.
2Reliability
If rinsing solution is used during eye surgery to reduce inflammation and infection, then tissue safety is improved, but the rinsing solution may become stained and obscure visibility of target tissue
Solution Approach 1:
By increasing the density of the staining composition through polymer addition, the dye remains localized to the target tissue and does not wash away into the rinsing solution. The dense composition sinks and stays in place, allowing rinsing to proceed without obscuring the surgical field.
Solution Approach 2:
The high molecular weight polymer acts as a sacrificial carrier that remains with the stained tissue and does not migrate to the rinsing solution. This allows the rinsing solution to remain clear and reusable, while the staining agent stays localized.
3Ease of operation
If conventional staining composition is used, then the dye can be applied to tissue, but rinsing may partially remove the dye, resulting in insufficient staining
Solution Approach 1:
The increased density of the staining composition causes it to sink rapidly and adhere to the tissue surface, making the dye resistant to removal by rinsing. The physical property change ensures the dye remains on the target tissue throughout the surgical procedure.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The increased density of the staining composition results in more precise targeting, intense local staining, reduced risk of collateral staining, and enhanced stability of the vital dye, facilitating safer and more effective eye surgery by maintaining clear visibility of target tissues.
Implementation Method 1
The staining composition will then be allowed to spread through this tissue by allowing the staining composition to sink onto or penetrate the tissue under the force of gravity.
Implementation Method 2
A staining composition comprising a vital dye and a density increasing compound chosen from the group consisting of water soluble polymers and small inert molecules.
Data Source
AI summary
The invention is directed to a staining composition and to the use of the staining composition in staining ocular tissue. In a first aspect, the invention provides a staining composition comprising a vital dye and a density increasing compound chosen from the group consisting of water soluble polymers and small inert molecules.