Dental Chelator Base Composition for Biofilm Pathogenicity
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Solution Overview
Problem
Current antibiotics are ineffective in inhibiting the pathogenic effects of biofilms and pose toxicity risks, necessitating the development of non-toxic compositions that can limit microbial adverse effects without disrupting healthy microbial flora.
Innovation Solution
Compositions comprising a synergistic combination of chelators and bases, such as cyclodextrin and sodium bicarbonate, are used to selectively inhibit pathogenic microbes while maintaining the viability of commensal flora, administered in various forms like tablets, mouthwashes, or topical applications.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Object-affected harmful factors
If antibiotics are used to inhibit pathogenic effects of biofilms, then microbial pathogenicity is reduced, but toxicity to mammals increases
Solution Approach 1:
The patent introduces chelators as intermediary substances that selectively bind to metal ions required by pathogenic microbes, thereby inhibiting their growth and pathogenicity. The chelators act as mediators between the therapeutic agent and the target microbe, providing selective toxicity without directly killing the microbe or causing harm to mammalian cells.
Solution Approach 2:
The invention modifies the chemical environment by changing metal ion availability through chelation. By altering the biochemical parameters of the microbial environment (specifically metal ion binding), the patent creates conditions that inhibit pathogenic microbial growth while maintaining compatibility with mammalian physiology.
2Object-affected harmful factors
If conventional antimicrobial agents are used to treat biofilms, then pathogenic microbial growth is inhibited, but disruption of healthy microbial flora increases
Solution Approach 1:
The patent applies local quality by creating a localized chemical environment through chelation that specifically targets pathogenic microbes based on their metal ion requirements. The chelators are designed to bind selectively to metals essential for pathogenicity, thereby affecting harmful microbes while leaving beneficial flora unaffected due to their different metal requirements.
Solution Approach 2:
The invention converts the harmful effect of metal ion availability for pathogenic microbes into a beneficial selective inhibition mechanism. By providing chelators that specifically sequester metals needed by pathogens, the patent transforms a potential harm (metal ion depletion affecting all microbes) into a benefit (selective inhibition of pathogenicity while preserving beneficial flora).
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
These compositions effectively limit microbial growth and metabolic activity of pathogenic microbes, promoting oral health and reducing the risk of conditions like cavities and gingivitis without harming beneficial microorganisms.
Implementation Method 1
compositions comprising a synergistic amount of chelator and base for limiting the adverse effects of microbes and microbial biofilms
Implementation Method 2
the base is selected from the group consisting of natural bases, synthetic bases and agents having basic properties
Data Source
AI summary
The present invention relates to non-toxic consumable compositions and formulations comprising chelator and base having synergistic effects on microbial metabolism and/or growth and/orpathogenic effectors and their use to promote and maintain health in mammals. The current invention also relates to non-toxic consumable compositions comprising more than one chelator and/or more than one base. The present invention further relates to methods for selecting said chelator and base composition and methods for detecting conditions in which selected compositions may be used. The present invention relates to the synergistic compositions and methods of their use for maintaing health, promoting health and treating diseases.