Dental Composition with Pelargonium sidoides and Hydroxyapatite Nanocrystals

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Solution Overview

Problem

Current dental and oral hygiene products, such as toothpastes and mouthwashes, often fail to effectively address infections and inflammations, particularly gingivitis, periodontitis, and dental sensitivity, despite containing active ingredients like fluoride and antibacterial agents, which may also cause adverse effects like enamel erosion and mouth ulcers.

Innovation Solution

A novel composition combining Pelargonium sidoides extract, Vitamin A, Vitamin C, Vitamin E, Folic acid, Niacinamide, Zinc, Coenzyme Q10, Arginine, Calcium carbonate, Fluoride, Strontium chloride, and Papain with standard toothpaste or mouthwash constituents, applied directly to teeth and gums for enhanced antibacterial, anti-inflammatory, and sensitivity-relief effects.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If fluoride and antibacterial agents are used in toothpaste, then cavity prevention and gingivitis prevention are improved, but enamel erosion and mouth ulcers occur

Engineering Contradiction:

Improvecavity preventionVSAvoidenamel erosion

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent changes the chemical parameters of the toothpaste by replacing traditional fluoride compounds with hydroxyapatite nanocrystals (Ca10(PO4)6(OH)2) and altering the antibacterial mechanism from triclosan to essential oils and zinc compounds. This parameter change maintains cavity prevention efficacy while eliminating enamel erosion caused by fluoride and reducing mouth ulcers caused by sodium lauryl sulfate

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The patent uses composite materials by combining hydroxyapatite nanocrystals with natural polymers (xanthan gum, carrageenan) and multiple active ingredients (essential oils, zinc compounds, arginine). This composite approach creates a synergistic effect that provides both protective and therapeutic functions without the harmful side effects of conventional ingredients

Inventive Principle:

Principle #40Composite materials

2Ease of operation

If sodium lauryl sulfate is used as foaming agent, then foaming action is improved, but mouth ulcers frequency increases

Engineering Contradiction:

Improvefoaming actionVSAvoidmouth ulcers

Core Design Contradiction:

Ease of operationVSObject-affected harmful factors

Solution Approach 1:

The patent changes the surfactant parameters by replacing sodium lauryl sulfate with milder alternatives such as sodium methyl cocoyl taurate and cocamidopropyl betaine. These alternative surfactants provide adequate foaming action while being less irritating to oral tissues, thereby reducing the frequency of mouth ulcers

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The patent applies different surfactant properties to different functions: using amphoteric surfactants (cocamidopropyl betaine) that provide both foaming and mucosal protection, while reserving essential oils and zinc compounds for targeted antibacterial action. This local quality differentiation ensures effective cleaning without widespread tissue irritation

Inventive Principle:

Principle #3Local quality

3Productivity

If abrasives are used in toothpaste, then plaque removal time is reduced, but enamel polishing action increases

Engineering Contradiction:

Improveplaque removal efficiencyVSAvoidenamel erosion

Core Design Contradiction:

ProductivityVSObject-affected harmful factors

Solution Approach 1:

The patent changes the abrasive parameters by using hydroxyapatite nanocrystals with controlled size (50-200 nm) and morphology. These nanocrystals provide effective plaque removal through their small size and high surface area, while their chemical similarity to tooth enamel (both are calcium phosphate-based) reduces harsh mechanical polishing action and enamel erosion

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The patent uses hydroxyapatite nanocrystals as an intermediary substance that bridges the gap between cleaning efficacy and enamel protection. These nanocrystals can adhere to both plaque and enamel surfaces, facilitating plaque removal while simultaneously reinforcing enamel structure through remineralization, thereby reducing net enamel loss

Inventive Principle:

Principle #24Intermediary (Mediator)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The composition provides broad-spectrum antibacterial and antifungal activity, reduces gingival inflammation, inhibits plaque formation, and offers relief from dental sensitivity, improving oral health beyond conventional products by targeting specific pathogens and inflammatory issues.

Implementation Method 1

Pelargonium sidoides extract has antiviral (herpes simplex virus), antibacterial (Staphylococcus aureus, Streptococcus pneumoniae), and antifungal (Candida albicans) activity against the causative organisms of oral disorders

Methodology Applied

Scientific EffectAntibacterial activity:

Implementation Method 2

Pelargonium sidoides extract has antiviral (herpes simplex virus), antibacterial (Staphylococcus aureus, Streptococcus pneumoniae), and antifungal (Candida albicans) activity

Methodology Applied

Scientific EffectAntifungal activity:

Implementation Method 3

Vitamin A as retinyl palmitate and its fomation of retinol can lead to an enrichment of vitamin A in buccal mucosal cells

Methodology Applied

Scientific EffectVitamin A enrichment:

Implementation Method 4

In this way metaplastic alterations of the buccal mucosal epithelium might be prevented or reversed by the application of topical retinyl palmitate

Methodology Applied

Scientific EffectPrevention of metaplastic alterations:

Implementation Method 5

Vitamin C can reduce the total supragingival calculus score

Methodology Applied

Scientific EffectCalculus reduction:

Implementation Method 6

Vitamin C can reduce the total supragingival calculus score and reduce the number of bleeding sites

Methodology Applied

Scientific EffectReduction of bleeding sites:

Implementation Method 7

Topical vitamin E may be an effective therapy in patients with chemotherapy-induced oral mucositis

Methodology Applied

Scientific EffectTherapy for oral mucositis:

Implementation Method 8

Coenzyme Q10: Topical application may improve adult periodontitis

Methodology Applied

Scientific EffectPeriodontitis improvement:

Implementation Method 9

Folic acid appears to have an influence on gingival health via local influence. There is significant improvement in gingival inflammation. Topically applied folinic acid may be effective in facilitating resolution of oral lesions. Niacinamide appears to have an influence on gingival health via local influence. There is significant improvement in gingival inflammation.

Methodology Applied

Scientific EffectGingival inflammation reduction:

Implementation Method 10

Zinc - Zinc citrate can enable significant inhibition of dental plaque formation

Methodology Applied

Scientific EffectPlaque formation inhibition:

Implementation Method 11

Arginine - Arginine may help to provide significantly increased dentin hypersensitivity relief. Calcium carbonate - Calcium carbonate may help to provide significantly increased dentin hypersensitivity relief

Methodology Applied

Scientific EffectHypersensitivity relief:

Implementation Method 12

Fluoride - Fluoride helps to prevent cavities, and has effects on the formation of dental enamel and bones

Methodology Applied

Scientific EffectCavity prevention:

Implementation Method 13

Strontium chloride - Strontium Chloride may be an effective means for reducing the discomfort and pain engendered by thermal and tactile stimuli in patients with dentinal hypersensitivity

Methodology Applied

Scientific EffectSensitivity reduction:

Implementation Method 14

Papain - Papain is a proteolytic enzyme with low specificity, suitable for cleaning the salivary protein plaque that has a whitening effect on the tooth surfaces

Methodology Applied

Scientific EffectProtein plaque cleaning: Enzyme

Data Source

PatentEP2588067B1Composition for dental health

Publication Date: 2016.10.26 TAYLOR G & CO LTD

AI summary

Composition in the form of a toothpaste or mouthwash for dental and oral hygiene, infections and inflammations, in which the active ingredients are Pelargonium sidoides extract, Vitamin A, Vitamin C, Vitamin E, Folic acid, Niacinamide, Zinc, Coenzyme Q1O, Arginine, Calcium carbonate, Fluoride, Strontium chloride, and Papain combined with standard constituents of toothpastes or mouthwashes.