Dentifrice with Ionic Tin and Phenyl Propanol for Gingivitis
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Solution Overview
Problem
Current antibacterial compositions for gingival inflammation are not sufficiently effective against bacteria that cause gum disease, leading to potential progression to periodontal disease and tooth loss.
Innovation Solution
A dentifrice composition containing ionic tin, caprylyl glycol, and one or both of 3-phenyl-1-propanol and phenethyl salicylate, with specific weight percentages, which provides improved antibacterial efficacy and stability.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional antibacterial compositions are used, then basic oral care is provided, but antibacterial efficacy against gingival inflammation bacteria is insufficient
Solution Approach 1:
The patent combines multiple antibacterial agents (ionic tin, caprylyl glycol, and 3-phenyl-1-propanol) into a single dentifrice composition. This merging of different antibacterial mechanisms creates a synergistic effect that significantly improves efficacy against gingival inflammation bacteria compared to conventional single-agent compositions.
Solution Approach 2:
The invention uses a composite antibacterial system comprising ionic tin in combination with caprylyl glycol and 3-phenyl-1-propanol. This composite approach leverages the complementary properties of each ingredient to achieve superior and more reliable antibacterial efficacy against the complex bacterial flora causing gingival inflammation.
2Reliability
If higher concentrations of antibacterial agents are used to improve efficacy, then antibacterial action is enhanced, but composition stability deteriorates
Solution Approach 1:
The patent optimizes the concentration parameters of each ingredient: ionic tin at 0.01-1.2%, caprylyl glycol at 0.01-1.2%, and 3-phenyl-1-propanol at 0.01-0.2%. These carefully controlled parameter ranges ensure both high antibacterial efficacy and galenic stability of the composition, avoiding the instability that would result from higher concentrations.
Solution Approach 2:
The invention assigns specific functional roles to different ingredients at optimized concentrations: ionic tin provides broad-spectrum antibacterial activity, caprylyl glycol enhances stability and contributes to the preservative system, and 3-phenyl-1-propanol provides additional antibacterial action. This localized optimization of each component's concentration and function achieves both efficacy and stability.
Data Source
AI summary
This invention relates to a dentifrice comprising (i) at least one source of ionic tin; and (ii) an antibacterial system comprising caprylyl glycol together with 3-phenyl-1-propanol, phenethyl salicylate, or both 3-phenyl-1-propanol and phenethyl salicylate, as well as to methods of using and of making these compositions.