Deodorant Formulation Stability via Antioxidant Synergy

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Solution Overview

Problem

Existing preparations for treating undesired body odor, particularly perspiration odor, face challenges with stability, high volatile organic compound (VOC) content, and potential formation of harmful decomposition products, especially when using triclosan and glycerol monoalkyl ethers like 1-(2-ethylhexyl) glycerol ether.

Innovation Solution

An active ingredient combination of glycerol ether, bispyridinium alkane, 1,2-propylene glycol, and vitamin E, optimized to enhance solubility and stability, reducing VOC content and preventing decomposition, even at elevated temperatures, by excluding aromatic alcohols and certain salts, and using specific weight ratios to create a clear, effective deodorant solution.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If triclosan is used as a bacteria inhibitor, then deodorizing effect is improved, but bacterial resistance develops and harmful decomposition products form

Engineering Contradiction:
Improvedeodorizing effectVSAvoidbacterial resistance and decomposition products
Core Design Contradiction:
ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent removes triclosan from the formulation entirely and replaces it with alternative active ingredients (glycerol monoalkyl ether and bispyridinium alkane) that achieve the desired deodorizing effect without the harmful side effects of bacterial resistance and decomposition product formation

Inventive Principle:
Principle #2Taking out (Extraction)

Solution Approach 2:

The patent uses glycerol monoalkyl ether, a biodegradable compound that breaks down into harmless substances, replacing persistent triclosan with a short-lived, environmentally friendly alternative that maintains effectiveness without long-term accumulation or resistance development

Inventive Principle:
Principle #27Cheap short-living objects (Disposable)

2Reliability

If glycerol monoalkyl ether is used at high concentration, then deodorizing effect is improved, but storage stability decreases at elevated temperatures

Engineering Contradiction:
Improvedeodorizing effectVSAvoidstorage stability
Core Design Contradiction:
ReliabilityVSStability of the object's composition

Solution Approach 1:

The patent creates a composite formulation combining glycerol monoalkyl ether with bispyridinium alkane and vitamin E, where the components work synergistically to maintain both high deodorizing effectiveness and storage stability at elevated temperatures, preventing the degradation issues seen with glycerol monoalkyl ether alone

Inventive Principle:
Principle #40Composite materials

Solution Approach 2:

The patent adds vitamin E as an antioxidant that prevents oxidative degradation of the glycerol monoalkyl ether before it can occur during storage, thereby maintaining stability at elevated temperatures while preserving the high concentration needed for effective deodorizing

Inventive Principle:
Principle #11Beforehand cushioning (Prior cushioning)

3Stability of the object's composition

If aromatic alcohols and certain salts are included, then solubility is improved, but VOC content increases and harmful decomposition products may form

Engineering Contradiction:
ImprovesolubilityVSAvoidVOC content and decomposition products
Core Design Contradiction:
Stability of the object's compositionVSObject-generated harmful factors

Solution Approach 1:

The patent explicitly excludes aromatic alcohols (such as 2-phenoxyethanol, benzyl alcohol) and certain salt compounds from the formulation, removing the source of VOC emissions and potential decomposition products while maintaining solubility through alternative means

Inventive Principle:
Principle #2Taking out (Extraction)

Solution Approach 2:

The patent achieves the solubility-enhancing function of aromatic alcohols through glycerol monoalkyl ether, which provides comparable or superior solubility properties without the harmful VOC emissions and decomposition issues associated with traditional aromatic alcohol preservatives

Inventive Principle:
Principle #26Copying

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The combination achieves long-term stability and efficacy against odor-causing microorganisms with reduced VOC content, providing effective control of body, mouth, and foot odors while maintaining skin compatibility and safety, comparable to higher concentrations of triclosan without its drawbacks.

Implementation Method 1

The combinations according to the invention are storage-stable, i.e. the formation of undesired decomposition products and the degradation of active ingredient are not observed even upon storage at elevated temperature

Methodology Applied
Scientific EffectAntioxidation: Oxidation

Implementation Method 2

The individual active ingredients a) glycerol ether and b) bispyridinium alkane are in each case in aqueous preparation soluble or clearly soluble and/or soluble or storage-stable at low temperatures only to a limited degree. By contrast, combinations according to the invention are (even at low temperatures) significantly more (storage)-stable and/or comprise active ingredient concentrations which are significantly above the solubility of the individual active ingredients (mutual solubility improvement of the components)

Methodology Applied
Scientific EffectSolubility enhancement: Solvation

Data Source

PatentEP2594248B1Active ingredient combination and use thereof
Publication Date: 2016.12.14 AIR LIQUIDE SANTE

AI summary

The invention relates to an active ingredient combination which comprises a) glycerol monoalkyl ether, b) bispyridinium alkane, c) polyol and d) antioxidant. The combination is advantageously used for producing a preparation for the treatment of undesired body odour, for example for producing a cosmetic deodorant preparation, an antidandruff hair cleansing composition, a preparation for the treatment of blemished skin and acne or a preparation for the treatment of foot and/or skin fungus.