Depressurized Sample Liquid Supply Container for Microchip Analysis
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Solution Overview
Problem
Microchips used in μ-TAS systems face challenges in introducing sample solutions due to air presence, which leads to prolonged introduction times, variations in sample amounts, and bubble generation, affecting analysis precision and efficiency.
Innovation Solution
A sample liquid supply container with a hermetically sealed depressurized region and a hollow needle system that uses negative pressure to suction air and introduce the sample solution, featuring sealing members with air-tightness and elasticity to ensure smooth and bubble-free injection.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If sample solution is introduced into the well or channel of a microchip, then the analysis function is achieved, but air existing in the well disturbs the introduction process and generates bubbles, deteriorating analysis precision
Solution Approach 1:
The patent applies preliminary action by providing air discharging portions that allow air to be removed from the well before sample solution introduction. The air discharging portions are positioned to enable air escape paths, preventing air interference and bubble generation during the subsequent sample introduction process, thereby maintaining analysis precision.
Solution Approach 2:
The patent extracts the harmful air from the well by providing dedicated air discharging portions. These portions create escape paths for air to leave the well, separating the air removal function from the sample introduction function, thus eliminating the harmful effect of air interference and bubble generation on analysis precision.
2Productivity
If sample solution is introduced into the well or channel of a microchip, then the analysis function is achieved, but the introduction process takes a long time, deteriorating analysis efficiency
Solution Approach 1:
The patent applies preliminary action by pre-configuring air discharging portions that enable rapid air removal before sample introduction. This preliminary air evacuation prevents resistance to sample flow, allowing the sample solution to be introduced quickly into the well without prolonged waiting time, thereby improving analysis efficiency.
Solution Approach 2:
The patent extracts air from the well through dedicated air discharging portions, removing the obstacle that would otherwise slow down sample introduction. By separating air removal from sample introduction, the system eliminates time delays caused by air interference, thus improving analysis efficiency.
3Measurement precision
If sample solution is introduced into the well or channel of a microchip, then the analysis function is achieved, but bubbles are generated in the well, deteriorating analysis precision
Solution Approach 1:
The patent applies preliminary action by providing air discharging portions that enable air to escape from the well before sample solution is introduced. This preliminary air removal prevents air from being trapped and forming bubbles during sample introduction, thereby maintaining analysis precision.
Solution Approach 2:
The patent extracts air from the well through air discharging portions, removing the source of bubble formation. By providing dedicated escape paths for air, the system prevents air from being trapped in the well during sample introduction, thus eliminating bubble generation and its harmful effects on analysis precision.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables rapid and precise introduction of sample solutions into microchips, reducing analysis time and improving precision by eliminating air interference and bubble formation.
Implementation Method 1
a first region which is depressurized therein and is hermetically sealed
Implementation Method 2
uses negative pressure to suction air and introduce the sample solution
Implementation Method 3
sealing members with air-tightness and elasticity
Implementation Method 4
hermetically sealed
Data Source
AI summary
A sample liquid supply container is disclosed. The sample liquid supply container includes a first region which is depressurized therein and is hermetically sealed, a second region which is able to receive a liquid therein, a first penetration portion, in which an interior of the first region is punctured by a hollow needle from outside, and a second penetration portion, in which an interior of the second region is punctured by the hollow needle inserted into the first penetration portion and reaches inside the first region.