Dequalinium Lactic Acid Composition for Bacterial Vaginosis
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Solution Overview
Problem
Current treatments for bacterial vaginosis (BV) often lead to relapses, antibiotic resistance, and side effects such as candidiasis, and fail to effectively promote the growth of lactobacilli, which are crucial for maintaining vaginal health.
Innovation Solution
A composition comprising dequalinium salt, maltodextrin, and lactic acid, which synergistically exerts an antibacterial effect while promoting the growth of lactobacilli, thereby restoring the vaginal ecosystem's pH and inhibiting pathogenic microorganisms.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If antibiotics are used to treat bacterial vaginosis, then pathogenic bacteria are eradicated, but relapses occur and antibiotic resistance develops
Solution Approach 1:
The patent converts the harmful effect of broad-spectrum antibiotics that kill both pathogenic and beneficial bacteria into a beneficial selective treatment. Dequalinium chloride is used at a concentration (0.1-10 mg/mL) that selectively eradicates pathogenic bacteria (Gardnerella vaginalis, anaerobes) while preserving lactobacilli, thereby eliminating the need for antibiotic rotation and reducing resistance development.
Solution Approach 2:
The patent changes the treatment parameter from broad-spectrum antibiotic coverage to selective antimicrobial action. By adjusting the concentration of dequalinium chloride and using it in combination with lactic acid (pH 3.5-4.5), the treatment achieves selective toxicity against pathogenic bacteria while sparing beneficial lactobacilli, thus preventing relapses caused by ecosystem disruption.
2Object-affected harmful factors
If broad-spectrum antibiotics are used, then pathogenic organisms are eliminated, but lactobacilli are also neutralized
Solution Approach 1:
The patent applies local quality by creating a selective chemical environment in the vaginal ecosystem. Lactic acid maintains pH 3.5-4.5, which is naturally favorable for lactobacilli, while dequalinium chloride at specific concentrations provides selective antimicrobial pressure that eliminates pathogenic bacteria without affecting lactobacilli. This localized chemical differentiation preserves beneficial flora while treating the infection.
Solution Approach 2:
Instead of using antibiotics that kill all bacteria and then hoping for beneficial flora recovery, the patent inverts the approach by using dequalinium chloride in combination with lactic acid to selectively eliminate pathogenic bacteria first, thereby preserving and even promoting lactobacilli growth from the outset. This inverted sequence prevents the ecological vacuum that leads to candidiasis and relapses.
3Productivity
If the vaginal ecosystem is disrupted, then pathogenic bacteria proliferate, but the natural protective mechanisms are weakened
Solution Approach 1:
The patent enables self-service by restoring the vaginal ecosystem's natural protective mechanisms. Lactic acid (0.1-10 mL per 100 mL solution) directly replenishes the acidic environment that lactobacilli naturally produce, while dequalinium chloride selectively removes pathogenic bacteria. This combination allows the ecosystem to self-regulate and maintain stability without continuous antibiotic intervention, preventing the cycle of disruption and recovery.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition effectively treats BV by inhibiting pathogenic bacteria growth and promoting lactobacilli proliferation, creating a favorable vaginal environment, with a reduced risk of relapses and side effects, and is stable in various forms for administration.
Implementation Method 1
lactic acid, the substance that has the key role of ensuring an acidic pH in the vaginal environment comprised between 3.5 and 4.5
Implementation Method 2
The composition comprises a dequalinium salt, maltodextrin and lactic acid for application in the treatment of the bacterial vaginosis... whose antibacterial effect is greater than the sum of the effects exerted by the individual substances
Implementation Method 3
maltodextrin... able to simultaneously promote the growth of the lactobacilli, naturally present in the vagina
Data Source
Figure 1
AI summary
The present invention relates to a composition comprising a dequalinium salt, maltodextrin and lactic acid for application in the treatment of the bacterial vaginosis. The inventor proposes an improved therapeutic strategy based on the action synergy of the three components of the composition, whose antibacterial effect is greater than the sum of the effects exerted by the individual substances. Furthermore, the aforementioned composition is able to simultaneously promote the growth of the lactobacilli, naturally present in the vagina. The composition according to the invention is stable both in a liquid solution and in a solid or semi-solid solution. The preferred form of administration is via the vaginal route, in the form of a liquid solution, a solid form such as ovules or semi-solid such as cream.