Dermal Composition Using DMSO to Reduce Skin Irritation
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Solution Overview
Problem
Existing formulations of permethrin and imidacloprid for dermal application often cause skin irritation and have limited solubility, making it difficult to achieve high efficacy while avoiding adverse reactions.
Innovation Solution
A composition comprising 35-55% permethrin, 5-15% imidacloprid, and 20-60% dimethyl sulfoxide, with optional excipients, which provides solubility, rapid absorption, and anti-oxidative properties, reducing skin irritation and enhancing treatment acceptance.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If high concentration of permethrin is used to achieve high efficacy against parasitic insects, then insecticidal effectiveness is improved, but skin irritation and adverse reactions increase
Solution Approach 1:
The patent uses dimethyl sulfoxide (DMSO) as an intermediary substance that serves multiple functions: it acts as a solvent for permethrin, enables controlled skin penetration, and reduces the direct irritant effect of high-concentration permethrin on the skin. The DMSO carrier system allows the active ingredient to be delivered effectively while mediating its interaction with the skin to minimize irritation.
Solution Approach 2:
The patent changes the physical and chemical parameters of the formulation by using DMSO as the carrier solvent, which has specific properties (polarity, penetration enhancement, solubility) that allow permethrin to be delivered at high concentrations without the same level of skin irritation as traditional carriers. This parameter change in the carrier system resolves the contradiction between efficacy and irritation.
2Stability of the object's composition
If traditional carrier solvents are used for permethrin and imidacloprid, then formulation stability is improved, but solubility of both active ingredients is limited
Solution Approach 1:
The patent employs dimethyl sulfoxide (DMSO) as a universal carrier solvent that can simultaneously dissolve both permethrin (a pyrethroid) and imidacloprid (a neonicotinoid) in high concentrations. DMSO's unique polar aprotic nature allows it to solvate diverse chemical structures, making it a multi-functional carrier that addresses the solubility limitations of traditional solvents while maintaining formulation stability.
3Adaptability or versatility
If multiple active ingredients are combined to broaden spectrum of activity, then efficacy against different parasites is improved, but formulation complexity and difficulty of achieving compatibility increase
Solution Approach 1:
The patent uses DMSO as an intermediary carrier that facilitates the compatibility of multiple active ingredients with different chemical properties. DMSO's ability to solvate both polar and non-polar compounds allows permethrin and imidacloprid to coexist in a stable formulation without precipitation or degradation, simplifying the formulation process despite the complexity of combining different insecticide classes.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition ensures high solubility and stability of both active ingredients, reduces skin irritation, and provides analgesic, anti-inflammatory, and anti-swelling effects, leading to improved treatment efficacy and acceptance for controlling parasitic insects.
Implementation Method 1
The composition ensures high solubility and stability of both active ingredients
Implementation Method 2
provides solubility, rapid absorption, and anti-oxidative properties
Implementation Method 3
provides solubility, rapid absorption, and anti-oxidative properties
Implementation Method 4
provides analgesic, anti-inflammatory, and anti-swelling effects
Data Source
Figure 1
AI summary
The present invention relates to a dermal composition for control of parasitic insects and acarides comprising imidacloprid and permethrin as active ingredients, dimethyl sulfoxide and optionally one or more veterinarily acceptable excipients.