Dermal Injector System with Multi-Needle Array for Precise Cell Delivery
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Solution Overview
Problem
Current injection devices fail to deliver substances like cells precisely and gently to specific tissue layers without applying pressure or shear stress, leading to damage and loss of viability, and lack reliability in targeting the optimal physiological site.
Innovation Solution
A dermal injector system with an electromechanical drive device, multiple needles, and a control unit that includes sensors and a user interface for precise control over needle depth, volume, and speed, along with a cooling feature to minimize pain and tissue damage.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Manufacturing precision
If a narrow cannula is used to deliver cells, then the injection precision is improved, but the shear stress and compression on cells increases causing damage and loss of viability
Solution Approach 1:
The injection device divides the single narrow cannula into multiple larger-bore cannulas arranged in an array. This segmentation allows the same injection precision to be achieved through multiple larger openings rather than one narrow opening, thereby reducing shear stress and compression on cells while maintaining targeting accuracy.
Solution Approach 2:
Multiple cannulas are combined into a single injection device array, where each cannula can be of larger diameter than a single narrow cannula would need to be. The combined effect of multiple larger-bore cannulas achieves the desired injection precision without the harmful effects of narrow bore geometry.
2Device complexity
If a standard syringe with hand-guided needle is used, then the device complexity is reduced, but the injection depth and angle cannot be controlled consistently
Solution Approach 1:
The hand-guided mechanical injection system is replaced with an electromechanical drive system that automatically controls needle advancement and retraction. This substitution provides precise, programmable control over injection depth and speed, ensuring consistency across multiple injections while maintaining relatively simple device operation.
Solution Approach 2:
The injection device incorporates dynamic control through the electromechanical drive system, which can adjust injection parameters such as depth, speed, and duration based on pre-programmed sequences. This dynamic control allows the device to adapt to different injection requirements while maintaining precision and consistency.
3Ease of operation
If cells are injected without pressure control, then the injection process is simpler, but cells experience harmful compression and shear stress
Solution Approach 1:
The injection device incorporates feedback control through sensors that monitor injection parameters and adjust pressure accordingly. This feedback mechanism ensures that cells are delivered with minimal compression and shear stress by maintaining pressure within optimal ranges, while the automated control keeps the operation relatively simple for the user.
Data Source
AI summary
The invention relates to an injection device which includes a handle and a guard which together enclose a movable cartridge which can contain liquid material to be injected, and further enclose a movable injector that includes a needle, the needle being attached to a housing where the housing is attached to the cartridge, the device also including a delivery mechanism whereby the needle is moved from a retracted to an extended position, and independently the volume of the chamber may be adjusted to expel the contents thereof through the needle and into a subject in need thereof. The injection device may be communicatively connected to a control unit so as to provide a dermal injection system.