Detachable Optical Measuring Insert for Sterilized Bioprocess Containers
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Solution Overview
Problem
Existing bioprocess vessels with optical sensors face thermal deformation issues during sterilization, leading to alignment deviations and necessitate costly corrections and replacements, which can result in inaccurate spectroscopic measurements.
Innovation Solution
A bioprocess vessel with a detachable optical measuring device that includes a port housing and a measuring insert, allowing the radiation-emitting and -receiving elements to be positioned accurately outside the vessel during sterilization, ensuring precise alignment and eliminating the need for post-sterilization corrections.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If the optical sensor is sterilized together with the bioprocess vessel, then the vessel is properly sterilized, but the optical sensor suffers thermal deformation and alignment deviations
Solution Approach 1:
The optical sensor is segmented from the bioprocess vessel by providing it with a separate housing that can be detached. This allows the sensor to be excluded from the sterilization process while the vessel is sterilized, preventing thermal deformation of the optical components while ensuring complete sterilization of the vessel.
Solution Approach 2:
The optical sensor is extracted from the sterilization process by providing a detachable housing that can be removed before sterilization. The housing includes a sealing arrangement that allows it to be disconnected from the vessel interior, enabling the sensor to be taken out of the high-temperature sterilization environment while maintaining the integrity of the sterilization process for the vessel.
2Device complexity
If the optical sensor remains installed during sterilization, then the setup is simpler, but post-sterilization alignment corrections are required
Solution Approach 1:
The optical sensor is preliminarily positioned in its housing with a sealing arrangement that enables easy connection and disconnection. This preliminary setup allows the sensor to be quickly installed or removed as needed, eliminating the need for time-consuming post-sterilization alignment corrections while maintaining installation simplicity.
3Temperature
If the optical sensor is exposed to high thermal load during sterilization, then the sterilization process is effective, but the sensor components may deform and misalign
Solution Approach 1:
The optical sensor is extracted from the high-temperature sterilization environment by providing a detachable housing that can be removed before sterilization. The housing includes a sealing arrangement that allows it to be disconnected from the vessel interior, enabling the sensor to be protected from thermal exposure while the vessel undergoes effective high-temperature sterilization.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The solution prevents thermal deformation of sensitive optical components, maintains precise alignment, and reduces the risk of measurement errors, thereby enhancing the accuracy and efficiency of spectroscopic measurements.
Implementation Method 1
at least one radiation-emitting element (124) designed to transmit electromagnetic radiation through the at least one fluid contained in the container housing (12)
Implementation Method 2
at least one radiation-receiving element (126) designed to receive at least part of the radiation emitted by the radiation-emitting element (124)
Data Source
Figure 1a~1b
Figure 2a~2b
Figure 3a~3b
AI summary
The invention relates to a bioprocess container (10) having an optical measuring device (100) for non-invasive spectroscopic measurement comprising: a container housing (12), a port housing (102), which is connected to the container housing (12) and is sealed off with respect to the interior (18) of the container housing (12); at least one radiation-emitting element (124), which is designed to transmit electromagnetic radiation through the at least one fluid contained in the container housing (12); at least one radiation-receiving element (126), which is designed to at least partly receive the radiation which was transmitted by the radiation-emitting element (124); and at least one measuring insert (122), which holds and supports the at least one radiation-emitting element (124) and/or the at least one radiation-receiving element (126).