Detection Base Board Layout for Multiplex AML Marker Sensing
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Solution Overview
Problem
Current methods for detecting acute myelogenous leukemia (AML) are invasive and lack sensitivity, relying on bone marrow biopsies for definitive diagnosis, which are painful for patients and not suitable for early detection.
Innovation Solution
A detection base board with a substrate containing a sample testing region comprising multiple detecting units, each with sensing electrodes and signal generating units, including bigrid transistors, connected by covalent bonds with antibodies, to generate electric signals for protein marker detection, increasing sensitivity and accuracy.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If bone marrow biopsy is used for definitive diagnosis, then diagnostic accuracy is improved, but patient comfort deteriorates due to pain
Solution Approach 1:
The patent replaces the mechanical invasive procedure of bone marrow biopsy with a biochemical detection system. The sensing unit detects protein markers in blood samples through antibody-antigen reactions, eliminating the need for physical bone marrow penetration while maintaining diagnostic capability for AML detection.
Solution Approach 2:
The patent introduces blood as an intermediary medium between the patient's disease state and the detection system. Instead of directly sampling bone marrow, the system detects protein markers in blood that serve as indirect indicators of AML, enabling non-invasive diagnosis while maintaining diagnostic accuracy.
2Measurement precision
If multiple protein markers are detected simultaneously, then diagnostic accuracy is improved, but device complexity increases
Solution Approach 1:
The patent merges multiple detection functions into a single integrated sensing unit. Multiple protein markers are detected simultaneously through multiple antibody-antigen reactions occurring in parallel within the same device structure, enabling comprehensive diagnostic capability without proportionally increasing device complexity.
Solution Approach 2:
The sensing unit is designed with multi-functionality to detect various protein markers (such as CD33, CD13, MPO) simultaneously. The same basic sensing mechanism can be configured to detect different markers, providing universal diagnostic capability for multiple AML indicators without requiring separate specialized devices for each marker.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The detection base board allows simultaneous identification of multiple AML-relevant protein markers, enhancing diagnosis accuracy and providing a non-invasive, high-efficiency clinical monitoring platform for AML.
Implementation Method 1
the sensing unit is configured to react with a sample to be detected and generate an electric signal
Implementation Method 2
the signal generating unit is configured to receive the electric signal and generate a detection current
Data Source
AI summary
A detection base board and a detection chip, which relates to the technical field of biological detection. The detection base board includes a plurality of detecting units, each of the detecting units includes a sensing unit and a signal generating unit, and the sensing unit and the signal generating unit are electrically connected; the sensing unit is configured to react with a sample to be detected and generate an electric signal, and the signal generating unit is configured to receive the electric signal and generate a detection current; the sensing unit includes a pair of sensing electrodes, and the pair of sensing electrodes are electrically connected to the signal generating unit; and both of the outer contours of the sensing electrodes include an arc line. The detection base board is used for the fabrication of high-sensitivity and high-accuracy detection chips.