Deviation Waveform Analysis for Rapid Coagulation Cause Estimation
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Solution Overview
Problem
Existing methods for determining the cause of blood coagulation disorders, particularly in patients taking direct oral anticoagulants (DOACs), are time-consuming and inefficient, leading to potential undetected abnormalities during emergencies.
Innovation Solution
A method involving the calculation of deviation curves and parameters from coagulation reaction curves to identify the cause of coagulation disorders, including DOACs positivity, by analyzing the difference between a subject and a reference specimen's coagulation reaction curves.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If conventional cross-mixing test is performed to determine the cause of extended coagulation time, then the cause can be identified, but the test requires very much time and effort
Solution Approach 1:
The patent extracts the essential diagnostic information from the coagulation reaction curve by calculating specific parameters (weighted average time, weighted average height, peak width, baseline length) that directly indicate the cause of coagulation disorder. This extraction method eliminates the need for time-consuming cross-mixing tests while maintaining diagnostic accuracy, as the parameters are calculated directly from the initial coagulation curve without requiring additional mixing and retesting
Solution Approach 2:
The patent performs preliminary analysis of the coagulation reaction curve immediately after obtaining the initial measurement, calculating diagnostic parameters before any cross-mixing procedures are needed. This preliminary action provides rapid cause identification, allowing clinicians to make immediate decisions about further testing or treatment without waiting for extended cross-mixing test results
2Measurement precision
If common presurgical coagulation test is performed on patients receiving DOACs administration, then coagulation time can be measured, but extension of coagulation time may not be observed causing undetected abnormalities
Solution Approach 1:
The patent applies local quality analysis by examining specific characteristics of the coagulation reaction curve rather than relying solely on overall coagulation time. By calculating localized parameters such as weighted average time, peak width, and baseline length at different phases of the coagulation reaction, the method can detect subtle abnormalities caused by DOACs that do not manifest as extended coagulation time, thereby improving detection precision and reliability
3Measurement precision
If multiple parameters are calculated from coagulation rate curve, then estimation of coagulation disorder cause can be improved, but calculation complexity increases
Solution Approach 1:
The patent segments the coagulation reaction curve into distinct phases and calculates specific parameters for each phase: weighted average time for the overall reaction, weighted average height for the peak phase, peak width for the acceleration phase, and baseline length for the initial phase. This segmentation allows accurate cause estimation through multiple parameters while maintaining manageable calculation complexity by focusing on specific, well-defined measurements rather than comprehensive curve analysis
Data Source
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AI summary
A method for estimating a cause for coagulation disorder in a blood specimen, the method comprising: calculating D(i), which is a deviation curve for a subject blood specimen; calculating a parameter reflecting a shape of D(i); and estimating a cause for coagulation disorder in the subject blood specimen on a basis of the parameter, wherein D(i) - P(i) - Pn(i), wherein i denotes measuring point number, or time, P(i) is a curve given by relativizing measurement data for coagulation reaction in the subject blood specimen to give a minimum value of 0 and a maximum value of A, Pn(i) is a curve given by shifting P'(i) to match a rising point thereof with a specific point X, wherein the P'(i) is a curve given by relativizing measurement data for coagulation reaction in a reference specimen to give a minimum value of 0 and a maximum value of A, A > 0, and X is from 5 to 15 seconds, or measuring point number corresponding thereto.