DHM, Milk Thistle, and PQQ Oral Formulation for Alcohol Damage
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Solution Overview
Problem
Existing compositions fail to effectively ameliorate the negative effects of alcohol consumption, such as hangovers and liver damage, without causing significant side effects.
Innovation Solution
A composition comprising dihydromyricetin (DHM), milk thistle extract, and pyrroloquinoline quinone (PQQ), preferably at least 98% pure, administered in oral tablets, capsules, or aerosols, to counteract alcohol-induced adverse effects.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Object-affected harmful factors
If existing compositions are used to reduce alcohol damage, then liver damage and hangover symptoms are ameliorated, but significant side effects are caused
Solution Approach 1:
The patent combines multiple active ingredients (acetaldehyde dehydrogenase activator, mitochondrial activator, antioxidant, and cell death inhibitor) into a single composition. This combination approach allows the synergistic effect of multiple compounds to effectively reduce alcohol-induced liver damage and hangover symptoms while minimizing the side effects that occur with individual compounds used at high doses
Solution Approach 2:
The patent optimizes the concentration and purity parameters of the active ingredients in the composition. By controlling the amount of each compound and ensuring high purity (at least 98% pure), the composition achieves effective protection against alcohol damage while reducing the likelihood of causing harmful side effects
2Reliability
If high purity compounds are used, then effectiveness is improved, but manufacturing complexity increases
Solution Approach 1:
The patent specifies a purity parameter of at least 98% for the active ingredients and establishes specific concentration ranges in the composition. These parameter specifications ensure high effectiveness while providing clear manufacturing guidelines that balance quality requirements with production feasibility
Solution Approach 2:
The patent creates a composite composition combining multiple purified compounds in specific ratios. This composite approach allows each component to be manufactured at high purity individually, then combined in a controlled process, achieving overall high effectiveness without requiring complex purification of the final mixture
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The combination significantly reduces hangover symptoms and enhances cognitive abilities while preventing liver damage, including hepatic steatosis, hepatitis, fibrosis, and cirrhosis, with minimal side effects.
Implementation Method 1
PQQ has been well known to as work as a cardioprotective agent, and it has been found to modulate myocardial oxidative stress, and protect myocardial cells from cell death. PQQ is also well known an anti-oxidant that works by scavenging oxygen radicals from oxidative stress-induced damage
Implementation Method 2
PQQ is also well known an anti-oxidant that works by scavenging oxygen radicals from oxidative stress-induced damage
Data Source
AI summary
Methods for reducing or mitigating concentration problems and dizziness associated with alcohol consumption are described, where a formulation is administered that includes effective amounts of a source of Dihydromycetin (DHM), a source of a milk thistle extract, and a source of Pyrroloquinoline quinone (PQQ) is provided. The source of each DHM and PQQ has at least 95 wt % of the compound. The source of the milk thistle extract has at least 60 wt % silymarin and at least 10 wt % of silybin. The composition is formulated in an orally administrable form consisting of a tablet, a capsule, and an aerosol form. The orally administrable form comprises 10-60 wt % of the DHM, 10-45 wt % of the milk thistle extract, and 0.5-10 wt % of the PQQ in the presence of at least 10 wt % of binder.