Topical Composition for Diabetic Foot Ulcer Healing
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Solution Overview
Problem
Current treatments for diabetic foot ulcers are often ineffective and have a high recurrence rate, posing a significant risk of amputation in diabetic patients, with existing methods being costly or painful and lacking in long-term efficacy.
Innovation Solution
A topical composition comprising beeswax, Hypericum extract, red grape vine extract, horse chestnut extract, Centella extract, and Aloe extract, which provides emollient and curative effects, forming a barrier to prevent skin dryness and infection, thereby slowing the progression of ulcers and promoting healing.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional treatments (hydrotherapy, ultrasound, nitric oxide-releasing hydrogels, Hyperbaric Oxygen) are used for diabetic foot ulcers, then some therapeutic effect is achieved, but the treatments are very costly and not easily available
Solution Approach 1:
The patent employs a topical composition that can be applied directly to the ulcer without requiring expensive medical equipment or infrastructure. The composition uses naturally derived ingredients that are inexpensive to produce, making the treatment accessible and affordable while maintaining therapeutic effectiveness for chronic wound management
Solution Approach 2:
The patent extracts and utilizes specific bioactive compounds from natural sources (plant extracts, beeswax, essential oils) to create a targeted topical treatment. This extraction approach isolates the therapeutic components needed for wound healing while eliminating the need for expensive medical equipment like hyperbaric oxygen chambers or ultrasound devices
2Reliability
If conventional treatments are applied to chronic wounds, then some healing effect is achieved, but the dosage regimens are very painful to the patient
Solution Approach 1:
The patent changes the physical and chemical parameters of the treatment by using a topical composition with specific viscosity, pH, and composition that allows gentle application. The formulation includes emollients and soothing ingredients that reduce pain during application while maintaining effective delivery of therapeutic compounds to the wound bed
Solution Approach 2:
The patent uses beeswax and plant extracts as intermediary substances that facilitate gentle delivery of therapeutic compounds. These natural ingredients act as mediators that reduce irritation and pain during application while ensuring effective transport of active compounds to the ulcer site
3Reliability
If known treatments are used for chronic wounds, then temporary healing may be achieved, but the recurrence rate is very high
Solution Approach 1:
The patent employs a topical composition designed for continuous application that maintains a sustained therapeutic presence on the wound. The formulation includes ingredients that provide ongoing antimicrobial, anti-inflammatory, and healing effects, preventing recurrence by continuously addressing the underlying causes of ulcer formation and persistence
Solution Approach 2:
The patent uses a composite formulation combining multiple natural ingredients (plant extracts, beeswax, essential oils, emollients) that work synergistically to address various aspects of wound healing simultaneously. This multi-component approach provides comprehensive protection against recurrence through combined antimicrobial, anti-inflammatory, moisturizing, and tissue-regenerative effects
Data Source
AI summary
The present invention relates to compositions comprising substances of natural origin for use in the treatment or preventing the onset or the aggravation of diabetic foot ulcers.