Targeted Gut Microbiome Delivery for Dialister spp. Expansion
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Solution Overview
Problem
Current methods fail to effectively increase the population of Dialister spp. in the gut microbiome, which is associated with various disease states and adverse conditions, lacking a proven approach to alleviate symptoms or prevent these conditions.
Innovation Solution
Direct delivery of specific vitamins or polyunsaturated fatty acids (PUFAs) such as beta-carotene, Vitamin A, Vitamin D, Vitamin B5, Vitamin B2, Vitamin K, DHA, EPA, and combinations thereof, directly to the large intestine to nourish the gut microbiome and increase Dialister spp. populations.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If vitamins or PUFAs are delivered directly to the large intestine, then the population of Dialister spp. increases, but the complexity of the delivery system increases
Solution Approach 1:
The invention segments the delivery system into two distinct components: (1) a delayed-release formulation that protects and transports vitamins/PUFAs through the upper gastrointestinal tract, and (2) a direct-to-colon delivery mechanism that releases the nutrients specifically in the large intestine. This segmentation allows the system to achieve targeted delivery without requiring entirely new complex technologies,而是利用已有的缓释和结肠靶向技术
Solution Approach 2:
The delayed-release formulation acts as an intermediary vehicle that protects the vitamins and PUFAs from degradation in the stomach and small intestine, and controls their release timing to coincide with arrival in the large intestine. This intermediary mechanism enables the active compounds to reach their target destination effectively
2Device complexity
If conventional vitamin delivery methods are used, then the delivery system remains simple, but the vitamins are not effectively delivered to the gut microbiome
Solution Approach 1:
The invention applies local quality by creating a delivery system with different release properties at different gastrointestinal locations. The formulation is designed to remain intact in the stomach and small intestine (where conventional delivery would release nutrients), and only releases vitamins/PUFAs in the large intestine (the target location). This spatially differentiated release pattern ensures that nutrients reach the gut microbiome effectively
Solution Approach 2:
The delayed-release formulation performs preliminary protection and transport functions before the vitamins/PUFAs reach the large intestine. The formulation is pre-engineered to withstand gastric acid and enzymatic degradation in the small intestine, ensuring that the active compounds remain intact until they reach their target destination in the colon
Data Source
AI summary
The population of Dialister spp. bacteria in the gut microbiome is lower in people with various diseases. We have found that administration of vitamins/vitamin combinations such as: beta-carotene, Vitamin A, Vitamin D, Vitamin B5, Vitamin B2, a combination of Vitamin B2 and Vitamin C, Vitamin K, DHA, or EPA, when administered directly to the large intestine, so that it provides nourishment to the gut microbiome directly, can result in an increase of Dialister spp.