Dialysate Bypass Control for Faster Blood Inlet Estimation

Resolve Bottlenecks,
Find Innovative Solutions
Generate Solutions

Solution Overview

Problem

Current extracorporeal blood treatment machines require lengthy bypass times to reach diffusive equilibrium for determining blood inlet values, leading to increased treatment time and patient discomfort, and previous methods for faster determination are limited to specific bypass times, causing repeated interruptions.

Innovation Solution

An extracorporeal blood treatment machine with a stored characteristic map or curve for a dialyzer-specific scaling factor allows determination of blood inlet values without predetermined bypass times, enabling flexible and efficient switching between main and bypass circuits based on real-time dialysate outlet values.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Measurement precision

If the blood treatment machine uses a predetermined bypass time to reach diffusive equilibrium for determining blood inlet values, then the determination accuracy is improved, but the treatment time increases and patient discomfort increases

Engineering Contradiction:
Improveblood inlet value determination accuracyVSAvoidtreatment time
Core Design Contradiction:
Measurement precisionVSLoss of time

Solution Approach 1:

The patent applies preliminary action by pre-calculating and storing scaling factors for multiple bypass times in a lookup table or characteristic curve during system initialization or calibration phase. When bypass is activated, the control unit can immediately retrieve the appropriate scaling factor based on the actual bypass duration without waiting for diffusive equilibrium, enabling fast determination of blood inlet values while maintaining accuracy through pre-computed correction factors.

Inventive Principle:
Principle #10Preliminary action

Solution Approach 2:

The patent replaces the physical/chemical process of waiting for diffusive equilibrium with a computational approach. Instead of mechanically timing the bypass until equilibrium is reached, the system uses a detection unit to measure dialysate outlet values and applies pre-stored scaling factors through mathematical calculation to determine blood inlet values, substituting the natural diffusion process with an engineered computational model.

Inventive Principle:
Principle #28Mechanics substitution (Replace mechanical system)

2Loss of time

If the blood treatment machine uses a shorter bypass time for faster determination, then the treatment time is reduced, but the determination accuracy deteriorates without proper correction

Engineering Contradiction:
Improvebypass timeVSAvoidblood inlet value determination accuracy
Core Design Contradiction:
Loss of timeVSMeasurement precision

Solution Approach 1:

The patent applies parameter changes by introducing scaling factors that vary with bypass time duration. The control unit selects or calculates the appropriate scaling factor based on the actual bypass time achieved, transforming the relationship between bypass time and determination accuracy. This allows the system to use variable bypass times while maintaining accuracy through dynamic parameter adjustment rather than requiring a fixed predetermined time.

Inventive Principle:
Principle #35Parameter changes

Solution Approach 2:

The patent creates a computational model (characteristic curve or lookup table) that copies the relationship between bypass time, diffusive equilibrium state, and blood inlet values. This model allows the system to simulate the effect of different bypass durations and select the appropriate correction factor, enabling accurate determination without actually waiting for equilibrium at each measurement point.

Inventive Principle:
Principle #26Copying

3Measurement precision

If the blood treatment machine requires repeated determinations due to fixed bypass time limitations, then the determination accuracy may be maintained, but the device complexity and operational complexity increase

Engineering Contradiction:
Improveblood inlet value determination accuracyVSAvoidsystem operational complexity
Core Design Contradiction:
Measurement precisionVSDevice complexity

Solution Approach 1:

The patent applies universality by designing a single scaling factor storage mechanism (lookup table or characteristic curve) that serves all bypass time durations. The control unit can handle any bypass time scenario using the same pre-stored data structure and retrieval logic, eliminating the need for multiple specialized determination procedures or repeated measurements, thereby reducing operational complexity while maintaining versatility across different bypass conditions.

Inventive Principle:
Principle #6Universality (Multi-functionality)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

This approach reduces overall treatment time by allowing bypass times to be selected as needed, improving efficiency and safety by eliminating the need for repeated determinations and minimizing patient discomfort.

Implementation Method 1

Within the dialyzer, the blood from the circulatory system and the dialysate from the dialysate circuit are brought into contact via a semipermeable membrane, allowing for the exchange of substances between the blood and the dialysate

Methodology Applied
Scientific EffectDiffusion: Diffusion

Implementation Method 2

Within the dialyzer, the blood from the circulatory system and the dialysate from the dialysate circuit are brought into contact via a semipermeable membrane, allowing for the exchange of substances between the blood and the dialysate

Methodology Applied
Scientific EffectOsmosis: Osmosis

Implementation Method 3

By adjusting the valve positions in the dialysis fluid circuit of the blood treatment machine, a certain volume of dialysis fluid remains on the dialysis fluid side of the dialyzer... only diffusion occurs between the confined volume of dialyzer fluid and the blood in the circulatory system

Methodology Applied
Scientific EffectDiffusive equilibrium: Diffusion

Data Source

PatentEP4655018B1Extracorporeal blood treatment machine and computer program therefor
Publication Date: 2026.03.11 B BRAUN AVITUM
  • EP4655018B1 patent drawingFigure 1
  • EP4655018B1 patent drawingFigure 2~3
  • EP4655018B1 patent drawingFigure 4~5

AI summary

The invention relates to an extracorporeal blood treatment machine (1) comprising: a dialyser (2); an extracorporeal blood circuit (5); a dialysate circuit (3) having fluidic switching means (26, 34, 40), with a main loop circuit and a bypass circuit; a detection unit (32a, 32b, 32c) which is designed to detect, at a dialysate outlet (2.2) of the dialyser (2) or downstream of the dialysate outlet (2.2), a dialysate outlet value (CDO) of a component in the dialysate, which outlet value correlates with a blood inlet value (CBI) of the component in the blood at a blood inlet (2.3) of the dialyser (2), and to provide a signal (CDOpre, CDOext) for the dialysate outlet value (CDO); and a control unit (54) which is designed to determine the blood inlet value (CBI) depending on the signals (CDOpre, CDOext for the dialysate outlet value (CDO) provided at the beginning of a bypass period (tBYP and after the bypass period (tBYP), and depending on a dialyser-specific factor (k) that depends on the bypass period (tBYP). At least one characteristic curve, preferably a characteristic map, of the dialyser-specific factor (k) is stored in a memory of the blood treatment machine (1), at least depending on the bypass period (tBYP), and can be retrieved in order to determine the blood inlet value (CBI). The invention also relates to a control method and to a computer program according to the additional independent claims.