Dialysate Flow Switching for Efficient Blood Return in Dialysis

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Solution Overview

Problem

Existing blood return methods in dialysis treatments, such as rehydration and back filtration, fail to effectively utilize the advantages of both processes, leading to inefficiencies in blood return due to occlusion of blood flow routes and excessive dialysate use.

Innovation Solution

A blood purification apparatus that switches between a first blood return process using a rehydration method and a second back filtration method, controlled by a dialysis apparatus with a controller to determine optimal dialysate flow routes based on predetermined flow and return amounts, ensuring efficient blood return with minimal dialysate usage.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Productivity

If rehydration method is used to return blood to the body, then blood return is achieved, but blood flow routes become occluded and dialysate consumption increases

Engineering Contradiction:
Improveblood return efficiencyVSAvoiddialysate consumption
Core Design Contradiction:
ProductivityVSLoss of substance

Solution Approach 1:

The patent segments the blood return process into two distinct methods: rehydration method (first blood return process) and back filtration method (second blood return process). The controller selectively switches between these two methods based on treatment conditions, allowing each method to be optimized for specific scenarios rather than using one method for all cases, thereby reducing overall dialysate consumption while maintaining effective blood return.

Inventive Principle:
Principle #1Segmentation

Solution Approach 2:

The system dynamically switches between rehydration and back filtration methods based on real-time treatment conditions monitored by the controller. This dynamic adaptation allows the system to respond to changing conditions such as blood flow rate, dialysate flow rate, and treatment time, optimizing blood return efficiency while minimizing dialysate usage in varying treatment scenarios.

Inventive Principle:
Principle #15Dynamics

2Productivity

If rehydration method is used to return blood to the body, then blood return is achieved, but the complexity of managing multiple flow routes increases

Engineering Contradiction:
Improveblood return efficiencyVSAvoidflow route management
Core Design Contradiction:
ProductivityVSDevice complexity

Solution Approach 1:

The dialysate circuit is designed to serve multiple functions: it can perform both rehydration (by directing dialysate through the connection flow route) and back filtration (by directing dialysate through the blood purification membrane). This multi-functionality reduces the need for separate dedicated systems for each blood return method, simplifying overall system management despite the presence of multiple flow routes.

Inventive Principle:
Principle #6Universality (Multi-functionality)

Solution Approach 2:

The controller monitors treatment conditions and provides feedback to automatically switch between rehydration and back filtration methods. This automated feedback control reduces the operational complexity of managing multiple flow routes by eliminating the need for manual intervention, allowing the system to self-regulate based on predetermined criteria and real-time conditions.

Inventive Principle:
Principle #23Feedback

3Productivity

If back filtration method is used to return blood to the body, then blood return is achieved, but excessive dialysate is consumed

Engineering Contradiction:
Improveblood return efficiencyVSAvoiddialysate flow amount
Core Design Contradiction:
ProductivityVSQuantity of substance

Solution Approach 1:

The patent applies partial action by using only the necessary amount of dialysate for each method. The rehydration method uses dialysate to push blood through the connection flow route, while the back filtration method uses dialysate to push blood through the blood purification membrane. By switching between methods, the system applies the minimum necessary dialysate flow for effective blood return in each scenario, avoiding excessive dialysate consumption.

Inventive Principle:
Principle #16Partial or excessive action

4Productivity

If automatic switching between methods is implemented, then optimal blood return is achieved, but control system complexity increases

Engineering Contradiction:
Improveblood return efficiencyVSAvoidcontroller complexity
Core Design Contradiction:
ProductivityVSDevice complexity

Solution Approach 1:

The controller uses feedback from monitored treatment conditions (blood flow rate, dialysate flow rate, treatment time) to automatically determine when to switch between rehydration and back filtration methods. This feedback mechanism simplifies the control logic by using predetermined switching criteria based on easily measurable parameters, reducing the overall complexity of the control system while maintaining optimal blood return efficiency.

Inventive Principle:
Principle #23Feedback

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The apparatus effectively combines rehydration and back filtration methods to ensure complete blood return with reduced dialysate consumption, addressing occlusion issues and optimizing blood recovery.

Implementation Method 1

a blood purifier (a hemodialysis treatment) to filter waste products and water in the blood

Methodology Applied
Scientific EffectFiltration: Filter (physical)

Implementation Method 2

causing the dialysate to push out the blood in the blood circuit

Methodology Applied
Scientific EffectPressure-driven flow: Pressure Gradient

Data Source

PatentUS12558467B2Blood purification apparatus
Publication Date: 2026.02.24 NIKKISO CO LTD
  • US12558467B2 patent drawing
  • US12558467B2 patent drawing
  • US12558467B2 patent drawing

AI summary

A blood circuit and a dialysate circuit bidirectionally circulate a fluid through a blood purification membrane of a blood purifier, and include a first flow route that causes a dialysate to flow from the dialysate circuit into the blood circuit through a connection flow route connecting the dialysate circuit to the blood circuit while bypassing the blood purifier, and a second flow route that causes the dialysate to flow from the dialysate circuit into the blood circuit through the blood purification membrane. The controller performs control such that blood in the blood circuit is returned to the body by feeding the dialysate to one of these flow routes, determine if a flow amount of the dialysate reaches a predetermined flow amount, and control such that the blood in the blood circuit is returned to the body by feeding the dialysate to the other one of these flow routes.