Peritoneal Dialysate Mixing With Sensor Feedback for Solute Control
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Solution Overview
Problem
Existing systems and methods for generating peritoneal dialysate cannot produce dialysate with specific and customizable solute concentrations, and they lack the ability to modify the composition based on individual patient needs, leading to suboptimal treatment outcomes.
Innovation Solution
A dialysate preparation system that includes conductivity sensors, flow meters, and composition sensors to control the addition of osmotic agents and ion concentrates, allowing for precise adjustment of solute concentrations and ensuring compliance with a dialysate prescription.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Adaptability or versatility
If premade dialysate formulations are used, then the system is simple to operate, but the solute concentrations cannot be customized for individual patients
Solution Approach 1:
The dialysate formulation is segmented into multiple separate concentrate sources (ion concentrates and osmotic agents) that can be independently controlled and mixed in customized ratios, allowing individual patient prescriptions while maintaining a relatively simple integrated delivery system
Solution Approach 2:
The system enables dynamic adjustment of solute concentrations by varying the flow rates and mixing ratios of different concentrate sources, allowing customization of dialysate composition parameters for individual patient needs
2Manufacturing precision
If sensors are added to measure solute concentrations, then the manufacturing precision of dialysate composition is improved, but the device complexity increases
Solution Approach 1:
Conductivity sensors and composition sensors provide real-time feedback on the actual solute concentrations in the generated dialysate, allowing the control system to adjust concentrate flow rates to maintain precise compliance with prescribed formulations
Solution Approach 2:
The system replaces complex manual formulation processes with automated electronic control of concentrate mixing, using sensors and control algorithms to achieve precise solute concentration control without requiring manual calculation and measurement
3Adaptability or versatility
If multiple concentrate sources are used to achieve specific solute concentrations, then the adaptability to patient needs is improved, but the ease of operation deteriorates
Solution Approach 1:
The integrated delivery system performs multiple functions (mixing, monitoring, and delivering customized dialysate formulations) through a single unified platform, allowing different concentrate sources to be managed through one control interface rather than separate systems
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables the generation of peritoneal dialysate with tailored solute concentrations, enhancing treatment efficacy by ensuring the dialysate meets individual patient requirements and maintaining sterility and safety standards.
Implementation Method 1
at least one or more conductivity sensors are positioned in the first fluid line
Implementation Method 2
the composition sensor and/or secondary composition sensor can be selected from the group consisting of a refractive index sensor, an enzyme-based sensor, and a pulsed amperometric detection sensor
Implementation Method 3
one or more osmotic agent sources fluidly connected to the first fluid line through one or more secondary infusate lines
Data Source
AI summary
The invention relates to devices, systems, and methods for generating a peritoneal dialysate having specified concentrations of one or more solutes. The devices, systems and methods use conductivity sensors, flow meters, and composition sensors to control addition of osmotic agents and ion concentrates into a peritoneal dialysate generation flow path.