Dialysis Acid Precursor Composition Moisture Barrier
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Solution Overview
Problem
Current dry dialysis precursor compositions face issues such as incompatibility of dry acid and bicarbonate, precipitation of calcium and magnesium carbonates, caking, lump formation, and glucose degradation, leading to instability and difficulty in preparing a ready-for-use dialysis solution due to humidity sensitivity.
Innovation Solution
A dialysis acid precursor composition comprising sodium chloride, citric acid or glucono-δ-lactone, anhydrous calcium chloride or calcium gluconate, magnesium chloride hexahydrate, and optional potassium salt and glucose, sealed in a moisture-resistant container with a water vapor transmission rate less than 0.3 g/m² at 38°C/90%RH, ensuring stability and preventing chemical degradation.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Duration of action of stationary object
If dry acid and bicarbonate are stored together in a dry precursor composition, then the composition can be prepared in advance and stored, but chemical degradation and incompatibility occur due to humidity sensitivity
Solution Approach 1:
The precursor composition is divided into separate compartments: a first compartment containing dry acid and a second compartment containing bicarbonate. This segmentation prevents direct contact between the two substances during storage, eliminating chemical degradation while allowing both components to be present in the same product. The compartments are separated by a barrier that prevents moisture transfer, resolving the contradiction between extended shelf life and chemical stability.
Solution Approach 2:
The harmful element (moisture) is extracted from the system by using a moisture barrier that prevents humidity from reaching the precursor components. This extraction of the degrading agent allows the dry acid and bicarbonate to be stored together indefinitely without chemical degradation, simultaneously achieving long shelf life and high reliability.
2Ease of manufacture
If all components are provided as dry components, then costs and environmental impact are reduced, but caking and lump formation occur due to humidity sensitivity
Solution Approach 1:
By segmenting the composition into separate compartments with a moisture barrier, the dry components remain isolated from humidity during storage and transport. This prevents caking and lump formation while maintaining the cost and environmental benefits of dry formulation. The barrier ensures that when the product is ready for use, the components can be easily dissolved without pre-existing lumps.
3Adaptability or versatility
If glucose is included in the dry precursor composition, then the dialysis solution can be prepared with glucose, but glucose degradation products form due to humidity sensitivity
Solution Approach 1:
The moisture barrier extracts and isolates glucose from harmful humidity during storage. This prevents glucose degradation while maintaining the flexibility to include glucose in the final dialysis solution. The barrier ensures glucose remains stable until preparation, eliminating harmful degradation products while preserving formulation versatility.
4Stability of the object's composition
If calcium and magnesium salts are stored with bicarbonate in dry form, then the composition remains stable during storage, but precipitation occurs during preparation due to solubility product exceeding
Solution Approach 1:
The composition is segmented into separate compartments: one containing calcium and magnesium salts, and another containing bicarbonate. This segmentation prevents premature precipitation during storage while allowing both components to be present. During preparation, the controlled mixing ensures proper dissolution before precipitation can occur, maintaining both storage stability and solution composition accuracy.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The solution provides improved stability, reduced chemical degradation, extended shelf life, cost savings, and environmental benefits by maintaining component compatibility and preventing caking, while ensuring proper dissolution and composition of the ready-for-use dialysis solution.
Implementation Method 1
sealed in a moisture-resistant container with a water vapour transmission rate less than 0.3 g/m²
Data Source
AI summary
The present invention concerns a dialysis acid precursor composition for use during preparation of a dialysis acid concentrate solution and for mixing with water and a bicarbonate containing concentrate into a ready-for-use dialysis solution. Said dialysis acid precursor composition consists of powder components comprising sodium chloride, at least one dry acid and at least one calcium salt, and optionally potassium salt, magnesium salt, and glucose. According to the invention said at least one calcium salt and said optional glucose, are present as anhydrous components in said dialysis acid precursor composition.