Dialysis Agent Water Content Control for Consolidation Prevention
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Solution Overview
Problem
Current dialysis agents face challenges with consolidation and aggregation, leading to reduced productivity and increased costs due to complex production processes and the need for precise concentration adjustments, especially when forming agents into granules.
Innovation Solution
A method involving a dialysis agent with magnesium chloride hydrate and calcium chloride hydrate as electrolytes, where each component is placed in a container as a single solid component, with controlled water content ratios to prevent consolidation and aggregation, using a drying treatment to achieve specific water content ranges for magnesium chloride hydrate (43-51%) and calcium chloride hydrate (1-22%) to enhance stability and handling.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If dialysis agents are formed into granules through complex granulation methods, then the agents can be handled more conveniently during storage and transport, but the production process becomes more complex, productivity decreases, and the risk of foreign matter contamination increases
Solution Approach 1:
The dialysis agent is divided into multiple independent granules, each containing a single electrolyte component. This segmentation allows each granule to be produced separately through simple drying processes rather than complex granulation, improving productivity while maintaining handling convenience through uniform granule size and shape
Solution Approach 2:
Electrolyte components are pre-dried to specific water content ranges before final assembly into the dialysis agent formulation. This preliminary drying action prevents consolidation and aggregation during storage, achieving convenient handling without requiring complex post-production granulation processes
2Stability of the object's composition
If granulation processes are used to produce dialysis agents, then the agents can be produced in solid form for better handling, but the number of unit operations increases leading to more complex production and higher risk of foreign matter contamination
Solution Approach 1:
The water component is extracted from electrolyte compounds to produce anhydrous or low-water-content forms that are inherently stable in solid state. This extraction eliminates the need for complex granulation processes while maintaining solid form stability for convenient handling and storage
Solution Approach 2:
The water content of electrolyte components is changed to specific ranges (e.g., magnesium chloride hydrate at 43-51% water content, calcium chloride hydrate at 1-22% water content) to optimize stability. This parameter control achieves solid form stability without requiring complex production processes
3Adaptability or versatility
If the concentration of electrolyte components is adjusted to create different varieties of dialysis agents, then the agents can meet different medical requirements, but production conditions must be re-established for each variety and raw material removal is required, deteriorating productivity
Solution Approach 1:
A core set of pre-dried electrolyte granules is created that can serve multiple dialysis agent formulations. By universally producing these base components with controlled water content, the same production conditions can be reused across different product varieties, maintaining productivity while achieving adaptability through different formulation combinations
Solution Approach 2:
Electrolyte components are pre-processed and dried to specific specifications before being incorporated into different dialysis agent formulations. This preliminary action creates universal building blocks that can be combined in various ratios to create different varieties without requiring re-establishment of production conditions
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach reduces consolidation and aggregation, simplifies production, improves productivity, and stabilizes the magnesium and calcium content, resulting in a cost-effective and high-quality dialysis agent with improved handling and storage properties.
Implementation Method 1
using a drying treatment to achieve specific water content ranges for magnesium chloride hydrate (43-51%) and calcium chloride hydrate (1-22%)
Data Source
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AI summary
Provided is a dialysis agent which includes at least magnesium chloride hydrate as electrolytes, and in which each of the constituent components is placed in a container as a single solid component, wherein consolidation and aggregation of the chemical agent are suppressed, and the dialysis agent can be obtained at low cost. Specifically, a dialysis agent which includes electrolytes containing at least magnesium chloride hydrate, and a pH modifier, wherein the ratio between the water content of the entire dialysis agent and the amount of water removed from the magnesium chloride hydrate is less than 118% but at least 7%, the water content of the magnesium chloride hydrate is within a range from 43% to 51%, and each of the constituent components is placed in a container as a single solid component.