Dialysis Machine Bicarbonate Flow Control

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Solution Overview

Problem

Dialysis machines often require frequent refills and pauses during treatment due to depletion of bicarbonate or acid concentrates, leading to inefficiencies and potential errors in resource management.

Innovation Solution

A computer-implemented method in dialysis machines that predicts when bicarbonate or acid levels will fall below a threshold, adjusting the dialysate flow rate to extend treatment time without degrading clearance values, using sensors to monitor conductivity and adjust the switching rate to conserve resources.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Productivity

If the dialysate flow rate is maintained at a high rate to ensure adequate clearance, then the treatment effectiveness is improved, but the bicarbonate or acid concentrate depletes faster requiring frequent refills

Engineering Contradiction:
Improvetreatment effectivenessVSAvoidtime until concentrate depletion
Core Design Contradiction:
ProductivityVSDuration of action of moving object

Solution Approach 1:

The system dynamically adjusts the dialysate flow rate based on real-time monitoring of concentrate levels and treatment progress. The flow rate is modulated to maintain adequate clearance while extending the duration before concentrate depletion, allowing the treatment to continue without interruption or pause for refilling.

Inventive Principle:
Principle #15Dynamics

Solution Approach 2:

The system changes the flow rate parameter of dialysate based on predicted depletion timelines and actual treatment needs. By adjusting this critical parameter, the system optimizes the balance between treatment effectiveness (clearance) and resource conservation (extend concentrate usage), resolving the contradiction between high productivity and extended duration.

Inventive Principle:
Principle #35Parameter changes

2Duration of action of moving object

If the dialysate flow rate is reduced to conserve bicarbonate or acid concentrate, then the duration of treatment is extended, but the clearance value may degrade below acceptable thresholds

Engineering Contradiction:
Improvetime until concentrate depletionVSAvoidclearance value
Core Design Contradiction:
Duration of action of moving objectVSProductivity

Solution Approach 1:

The system continuously monitors treatment progress, concentrate levels, and clearance metrics, using this feedback to dynamically adjust the dialysate flow rate. This closed-loop control ensures that flow rate reductions to conserve concentrate do not cause clearance values to fall below acceptable thresholds, maintaining both extended duration and adequate productivity.

Inventive Principle:
Principle #23Feedback

Solution Approach 2:

Rather than using a static flow rate, the system employs dynamic adjustment based on real-time conditions. The flow rate is modulated to maintain clearance above minimum thresholds while maximizing the duration of concentrate usage, allowing the system to adapt to changing treatment conditions and resource levels.

Inventive Principle:
Principle #15Dynamics

3Device complexity

If manual monitoring and refilling of concentrates is used, then the system complexity is low, but treatment interruptions and operator errors increase

Engineering Contradiction:
Improvesystem automation levelVSAvoidtreatment continuity
Core Design Contradiction:
Device complexityVSReliability

Solution Approach 1:

The system autonomously monitors concentrate levels, predicts depletion times, and adjusts dialysate flow rates without operator intervention. This self-service capability eliminates manual monitoring and refilling operations, thereby reducing treatment interruptions and operator errors while maintaining treatment continuity and reliability.

Inventive Principle:
Principle #25Self-service

Solution Approach 2:

The automated system continuously monitors treatment parameters and concentrate levels, using feedback loops to make real-time adjustments to flow rates and predict depletion events. This automated feedback mechanism replaces manual monitoring, significantly improving treatment reliability by preventing interruptions and reducing human error.

Inventive Principle:
Principle #23Feedback

4Duration of action of moving object

If larger volume containers are used to extend treatment duration, then the frequency of refills is reduced, but the device complexity and space requirements increase

Engineering Contradiction:
Improvetreatment duration per containerVSAvoidcontainer management system
Core Design Contradiction:
Duration of action of moving objectVSDevice complexity

Solution Approach 1:

Instead of changing container size, the system changes the flow rate parameter to extend the duration that existing container volumes can support. By reducing and modulating the flow rate based on real-time conditions, the system maximizes the utilization of available concentrate volumes without requiring larger containers or more complex storage infrastructure.

Inventive Principle:
Principle #35Parameter changes

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

This approach ensures that dialysis treatments can continue without interruption, optimizing resource use and reducing the need for mid-treatment refills by accurately predicting and managing the depletion of bicarbonate or acid concentrates.

Implementation Method 1

using sensors to monitor conductivity

Methodology Applied
Scientific EffectConductivity measurement: Conduction (electrical)

Implementation Method 2

A semi-permeable membrane in the dialyzer separates the blood from the dialysate within the dialyzer and allows diffusion and osmosis exchanges to take place between the dialysate and the blood stream across the membrane

Methodology Applied
Scientific EffectDiffusion: Diffusion

Implementation Method 3

A semi-permeable membrane in the dialyzer separates the blood from the dialysate within the dialyzer and allows diffusion and osmosis exchanges to take place between the dialysate and the blood stream across the membrane

Methodology Applied
Scientific EffectOsmosis: Osmosis

Data Source

PatentUS20250018099A1Dialysis Treatment and Machine
Publication Date: 2025.01.16 FRESENIUS MEDICAL CARE HOLDINGS INC
  • US20250018099A1 patent drawing
  • US20250018099A1 patent drawing
  • US20250018099A1 patent drawing

AI summary

The disclosure relates to a method including determining a treatment time of a dialysis treatment for a patient, receiving, from at least a sensor of a dialysis machine, a dialysate flow rate, the dialysate comprising bicarbonate pumped out of a bicarbonate source, wherein the bicarbonate source has an initial amount of bicarbonate, and predicting that by end of the dialysis treatment no more than a threshold amount of bicarbonate will be left in the bicarbonate source, and in response, determining that a clearance value during the treatment is or will be higher than the threshold clearance value, and sending, to a balancing system, an instruction to reduce the dialysate flow rate to a reduced rate, wherein the reduced rate results in reducing a rate of bicarbonate pumped out of the bicarbonate source while maintaining a clearance value of the treatment at no less than the threshold clearance value.