Dialysis Machine Bicarbonate Flow Rate Prediction

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Solution Overview

Problem

Dialysis machines often require frequent refills and pauses during treatment due to depletion of bicarbonate or acid concentrates, leading to inefficiencies and potential errors in resource management.

Innovation Solution

A method and system for a dialysis machine that predicts when bicarbonate or acid levels will fall below a threshold, adjusting the dialysate flow rate to extend treatment time without degrading clearance values, using sensors to monitor and adjust the flow rate based on treatment time, remaining resource levels, and conductivity measurements.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If the dialysate flow rate is maintained at a high rate throughout treatment, then the clearance value is improved, but the bicarbonate source depletes faster requiring mid-treatment refills

Engineering Contradiction:
Improveclearance valueVSAvoidbicarbonate source duration
Core Design Contradiction:
ReliabilityVSDuration of action of moving object

Solution Approach 1:

The system dynamically adjusts the dialysate flow rate based on real-time monitoring of bicarbonate levels and predicted depletion timing. The flow rate is modified during treatment to extend bicarbonate source duration while maintaining clearance values within acceptable ranges, resolving the contradiction between maintaining high clearance and extending resource duration

Inventive Principle:
Principle #15Dynamics

Solution Approach 2:

The system implements continuous feedback by monitoring bicarbonate levels, calculating predicted depletion times, and comparing these against remaining treatment time. Based on this feedback loop, the system automatically adjusts flow rates to prevent mid-treatment refills while maintaining effective clearance, addressing both the reliability and duration concerns

Inventive Principle:
Principle #23Feedback

2Duration of action of moving object

If the dialysate flow rate is reduced to extend treatment time, then the bicarbonate source duration is improved, but the clearance value deteriorates

Engineering Contradiction:
Improvebicarbonate source durationVSAvoidclearance value
Core Design Contradiction:
Duration of action of moving objectVSReliability

Solution Approach 1:

Rather than using a static reduced flow rate, the system employs dynamic adjustment where the flow rate is modified in real-time based on predicted bicarbonate depletion and remaining treatment needs. This allows the system to extend bicarbonate source duration while preventing clearance values from falling below acceptable thresholds

Inventive Principle:
Principle #15Dynamics

Solution Approach 2:

The system changes the flow rate parameter dynamically during treatment based on calculated depletion predictions. By adjusting this critical parameter in response to real-time conditions, the system extends bicarbonate source duration while maintaining clearance values within acceptable ranges

Inventive Principle:
Principle #35Parameter changes

3Reliability

If mid-treatment refills are performed to maintain clearance values, then the clearance value is maintained, but treatment interruptions and errors increase

Engineering Contradiction:
Improveclearance valueVSAvoidtreatment continuity
Core Design Contradiction:
ReliabilityVSEase of operation

Solution Approach 1:

The system performs preliminary calculations of bicarbonate depletion timing before depletion actually occurs. By predicting depletion points in advance and proactively adjusting flow rates, the system prevents the need for mid-treatment refills, maintaining both clearance values and treatment continuity without interruptions

Inventive Principle:
Principle #10Preliminary action

Solution Approach 2:

The system autonomously monitors bicarbonate levels, predicts depletion timing, and self-adjusts flow rates to prevent depletion-related interruptions. This self-service capability eliminates the need for operator intervention for refills, maintaining treatment continuity while ensuring clearance values are preserved

Inventive Principle:
Principle #25Self-service

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

This approach ensures that dialysis treatments can continue without interruption, optimizing resource use and reducing the need for mid-treatment refills, while maintaining effective clearance values within specified thresholds.

Implementation Method 1

A semi-permeable membrane in the dialyzer separates the blood from the dialysate within the dialyzer and allows diffusion and osmosis exchanges to take place between the dialysate and the blood stream across the membrane

Methodology Applied
Scientific EffectDiffusion: Diffusion

Implementation Method 2

A semi-permeable membrane in the dialyzer separates the blood from the dialysate within the dialyzer and allows diffusion and osmosis exchanges to take place between the dialysate and the blood stream across the membrane

Methodology Applied
Scientific EffectOsmosis: Osmosis

Implementation Method 3

A semi-permeable membrane in the dialyzer separates the blood from the dialysate within the dialyzer

Methodology Applied
Scientific EffectSemipermeable membrane: Semipermeable Membrane

Implementation Method 4

Current machines test depletion of bicarbonate using conductivity sensors

Methodology Applied
Scientific EffectElectrical conductivity: Conduction (electrical)

Data Source

PatentUS20250018098A1Dialysis Treatment and Machine
Publication Date: 2025.01.16 FRESENIUS MEDICAL CARE HOLDINGS INC
  • US20250018098A1 patent drawing
  • US20250018098A1 patent drawing
  • US20250018098A1 patent drawing

AI summary

The disclosure relates to a dialysis machine that comprises a dialyzer, a fluid source, a first line connected to the fluid source, and a container containing bicarbonate. The container connects to the first line and the fluid flows from the fluid source, through the first line, to the container. The dialysis machine further includes a second line connected to the container, a flow rate sensor connected to at least one of the lines, a pressure sensor configured for detecting fluid pressure of the container, a display, and a data processing apparatus. The data processing apparatus is configured to receive signals from the flow rate sensor and the pressure sensor. The data processing apparatus is configured to calculate a size of the container based on the received signals.