Dialysis Fluid Flow Rate Determination for Extracorporeal Blood Treatment

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Solution Overview

Problem

Existing dialysis machines operate with constant dialysis fluid flow, leading to high costs and inefficiency, as they require high dialysis fluid flows to achieve high clearance, which is not economically viable, and there is a need for a method to optimize dialysis fluid and blood flow rates to achieve effective dialysis with minimal fluid consumption.

Innovation Solution

A device and method that determine optimal dialysis fluid or blood flow rates based on specific criteria to maximize treatment effectiveness while minimizing fluid consumption, using a computing unit to calculate the optimal flow rates as a function of blood flow, dialysis fluid flow, and mass transfer coefficients, and storing these in a memory for different dialyzers, allowing for automatic adjustment during treatment.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Productivity

If high dialysis fluid flow is used to achieve high clearance, then dialysis effectiveness is improved, but dialysis fluid consumption increases

Engineering Contradiction:
ImproveclearanceVSAvoiddialysis fluid consumption
Core Design Contradiction:
ProductivityVSLoss of substance

Solution Approach 1:

The patent applies dynamics by making the dialysis fluid flow rate adjustable and adaptable during treatment. The system dynamically determines optimal flow rates based on patient-specific parameters (body weight, surface area, age) and treatment conditions, allowing the flow rate to be optimized in real-time rather than using fixed high flows. This resolves the contradiction by enabling high clearance when needed while reducing fluid consumption during sufficient treatment phases.

Inventive Principle:
Principle #15Dynamics

Solution Approach 2:

The patent changes the parameter of dialysis fluid flow rate from a fixed high value to a variable parameter determined by calculation. The system calculates optimal flow rates based on multiple parameters including patient characteristics, dialyzer properties, and treatment goals. This parameter change allows the system to achieve high clearance when necessary while minimizing fluid consumption when lower flows are sufficient, directly resolving the technical contradiction.

Inventive Principle:
Principle #35Parameter changes

2Reliability

If constant high dialysis fluid flow is used, then clearance is maintained, but treatment efficiency decreases due to excessive fluid consumption

Engineering Contradiction:
Improveclearance maintenanceVSAvoidtreatment efficiency
Core Design Contradiction:
ReliabilityVSProductivity

Solution Approach 1:

The patent implements feedback by continuously monitoring treatment progress and patient response, then using this information to adjust the dialysis fluid flow rate. The system calculates whether the current flow rate is achieving the desired clearance and adjusts accordingly. This feedback mechanism ensures reliable clearance maintenance while improving treatment efficiency by avoiding excessive fluid consumption once adequate clearance is achieved.

Inventive Principle:
Principle #23Feedback

Solution Approach 2:

The system transitions from static constant flow to dynamic adaptive flow. The dialysis fluid flow rate is continuously adjusted based on real-time assessment of treatment effectiveness and patient response. This dynamic approach maintains reliable clearance when needed while improving overall treatment efficiency by reducing fluid consumption during phases where lower flows are sufficient.

Inventive Principle:
Principle #15Dynamics

3Ease of operation

If manual flow rate setting is used, then operational flexibility is improved, but optimization of fluid consumption is insufficient

Engineering Contradiction:
Improveflow rate adjustmentVSAvoiddialysis fluid consumption
Core Design Contradiction:
Ease of operationVSLoss of substance

Solution Approach 1:

The patent applies self-service by enabling the system to automatically calculate and determine the optimal dialysis fluid flow rate without requiring manual optimization by the operator. The system uses built-in algorithms that consider patient parameters, dialyzer characteristics, and treatment goals to self-determine the optimal flow rate. This maintains operational flexibility while significantly improving fluid consumption optimization beyond what manual setting can achieve.

Inventive Principle:
Principle #25Self-service

Solution Approach 2:

The patent replaces manual mechanical adjustment with automated computational determination. Instead of relying on operator experience and manual flow rate setting, the system uses computational algorithms to automatically calculate optimal flow rates. This substitution maintains ease of operation (as the system is user-friendly) while dramatically improving fluid consumption optimization through precise calculation rather than manual estimation.

Inventive Principle:
Principle #28Mechanics substitution (Replace mechanical system)

Data Source

PatentEP2068972B1Device and method for determining a dialysis fluid flow rate or blood flow rate for extracorporeal blood treatment
Publication Date: 2013.11.06 FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH
  • EP2068972B1 patent drawingFigure 1
  • EP2068972B1 patent drawingFigure 2~3
  • EP2068972B1 patent drawingFigure 4~5

AI summary

The invention relates to a device (18) and to a method for determining the dialysis fluid flow rate for an extracorporeal blood treatment device. The dialysis fluid flow rate Qd is determined in accordance with the blood flow rate Qb or the blood flow rate Qb is determined in accordance with the dialysis fluid flow rate Qd, wherein by increasing about a specific value, the increase of a variable characterising the efficiency of the blood treatment, in particular clearance K, does not exceed the specific value. The invention also relates to a blood treatment device comprising a device (18) for determining the dialysis fluid flow rate or blood flow rate and to a method for operating an extracorporeal blood treatment device. As a result, an optimal dialysis fluid flow rate and/or blood flow rate calculates the requirement in accordance with a high efficiency of the dialysis treatment and in accordance with a reduced consumption of the dialysis liquid.