Fluid Removal Rate Compensation During Dialysis Pump Downtime

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Solution Overview

Problem

During extracorporeal blood treatment, pump stoppages due to events like reservoir changes or alarms result in incomplete patient fluid removal, necessitating a method to compensate for the lost fluid volume.

Innovation Solution

A system and method to calculate and increase the patient fluid removal rate (PFR) based on prescribed volumes and time of stoppages, using a PFR makeup volume to ensure the total fluid removal matches the prescribed rate.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If pump stoppages occur due to reservoir changes or alarms, then operational interruptions are necessary for maintenance or safety, but patient fluid removal volume is lost during these stoppages

Engineering Contradiction:
Improvetreatment continuityVSAvoidpatient fluid removal volume
Core Design Contradiction:
ReliabilityVSLoss of substance

Solution Approach 1:

The system calculates the expected fluid removal volume during the prescribed treatment time before the treatment starts. This preliminary calculation allows the system to identify the deficit caused by stoppages and compensate for it by adjusting pump rates during subsequent operational periods, ensuring the total fluid removal matches the prescription.

Inventive Principle:
Principle #10Preliminary action

Solution Approach 2:

The system dynamically changes the pump flow rate parameter during treatment based on the calculated fluid removal deficit. When stoppages occur, the pump rate is increased during subsequent operational periods to compensate for the lost fluid removal volume, while maintaining patient safety through monitored adjustments.

Inventive Principle:
Principle #35Parameter changes

2Manufacturing precision

If manual intervention is required to compensate for fluid loss during stoppages, then nurses can adjust treatment parameters, but workload increases and accuracy may be compromised

Engineering Contradiction:
Improvefluid removal accuracyVSAvoidnurse workload
Core Design Contradiction:
Manufacturing precisionVSEase of operation

Solution Approach 1:

The system automatically calculates the fluid removal deficit caused by stoppages and adjusts pump rates without requiring manual intervention from nurses. The control system monitors treatment progress, identifies volume deficits, and autonomously modifies operational parameters to ensure accurate fluid removal, reducing nurse workload while maintaining precision.

Inventive Principle:
Principle #25Self-service

Solution Approach 2:

The system continuously monitors actual fluid removal volume against the prescribed volume and uses this feedback to adjust pump rates in real-time. This closed-loop control ensures accurate compensation for stoppage-related losses without requiring manual calculation or intervention, maintaining both precision and ease of operation.

Inventive Principle:
Principle #23Feedback

3Productivity

If pump rates are increased to compensate for fluid loss, then total fluid removal can match prescription, but risk of patient hypotension or other complications increases

Engineering Contradiction:
Improvefluid removal rateVSAvoidpatient safety risk
Core Design Contradiction:
ProductivityVSObject-affected harmful factors

Solution Approach 1:

The system applies partial compensation by increasing pump rates only during specific operational periods after stoppages, rather than continuously maximizing the rate. This controlled approach compensates for fluid loss while distributing the increased stress over time, reducing the risk of acute hypotension or other complications compared to sudden high-rate compensation.

Inventive Principle:
Principle #16Partial or excessive action

Solution Approach 2:

The system dynamically adjusts pump rates based on real-time treatment conditions, patient responses, and accumulated fluid removal deficits. Rather than applying fixed rate increases, the control system modulates pump speed continuously, allowing flexible compensation that adapts to changing patient conditions and minimizes safety risks while achieving the prescribed total fluid removal.

Inventive Principle:
Principle #15Dynamics

Data Source

PatentEP3793634B1Calculation of the patient fluid removal rate to compensate for the volume of fluid not removed because of machine down times.
Publication Date: 2025.12.03 GAMBRO LUNDIA AB
  • EP3793634B1 patent drawingFigure 1
  • EP3793634B1 patent drawingFigure 2
  • EP3793634B1 patent drawingFigure 3

AI summary

A patient fluid removal compensation volume may be determined to make up for the patient fluid removal that does not occur during machine down times, and the patient fluid removal rate may be increased until the compensating volume is satisfied.