Dialysis Formulation Selenium Trace Element Segmentation
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Solution Overview
Problem
Current dialysis treatments often lead to imbalances in trace element levels, with some elements decreasing or increasing during treatment, and existing products do not allow for selective replacement of individual trace elements, particularly selenium, which can result in deficiencies and associated oxidative stress and inflammation.
Innovation Solution
A dialysis formulation containing selenium, optionally with rubidium, and potentially other trace elements like cobalt, molybdenum, and zinc, is provided in specific concentrations to maintain physiological levels and prevent deficiencies, especially in diabetic patients at risk for oxidative stress and atherosclerosis.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional dialysis treatment is used, then uremic toxins are removed from blood, but trace element levels become imbalanced (selenium deficiency occurs)
Solution Approach 1:
The invention segments the trace element supplementation by providing separate dialysis fluids containing individual trace elements (selenium, zinc, copper, manganese, chromium) rather than a universal mixture. This allows selective replacement of specific trace elements that are depleted during dialysis, particularly selenium, without risking accumulation of others.
Solution Approach 2:
The invention applies local quality by tailoring the dialysis fluid composition to specific patient needs and specific trace element deficiencies. Different dialysis fluids with different trace element compositions can be selected based on individual patient requirements, allowing localized optimization of trace element levels.
2Reliability
If dialysis treatment is performed, then blood is filtered, but oxidative stress and inflammation increase due to trace element imbalances
Solution Approach 1:
The invention applies preliminary anti-action by pre-supplementing trace elements (particularly selenium) in the dialysis fluid before and during the dialysis procedure. This prevents the oxidative stress and inflammation that would otherwise occur during treatment, rather than treating these effects after they manifest.
Solution Approach 2:
The invention converts the harmful effect of trace element depletion and the subsequent oxidative stress into a beneficial outcome by adding trace elements to the dialysis fluid. The same dialysis process that causes depletion is transformed into a means of supplementation through carefully formulated dialysis fluids.
3Ease of operation
If existing dialysis products are used, then general dialysis function is provided, but selective replacement of individual trace elements is not possible
Solution Approach 1:
The invention segments the dialysis fluid system into multiple specialized fluids, each containing specific trace elements. This segmentation enables selective replacement of individual trace elements while maintaining ease of operation through standardized fluid delivery systems.
Solution Approach 2:
The invention creates a universal dialysis fluid system that can serve multiple functions: standard dialysis, trace element supplementation, and selective trace element replacement. The same infrastructure supports both routine dialysis and customized trace element management.
Data Source
Figure 1A~1D
Figure 1E~1H
Figure 2
AI summary
The invention relates to a dialysis formulation, optionally a citrate containing dialysis formulation, comprising selenium (Se), optionally in combination with further trace elements selected from rubidium (Rb), cobalt (Co), molybdenum (Mo), and zinc (Zn). The dialysis formulation is intended to be used in dialysis treatment.