Dialysis Recirculation Detection Using Priming Fluid Signals

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Solution Overview

Problem

Existing methods for detecting recirculation in extracorporeal blood treatment, such as hemodialysis, require explicit bolus doses and blood sampling, which are invasive and disrupt the treatment process.

Innovation Solution

An extracorporeal blood treatment machine and method that uses the priming fluid already used for circuit flushing to detect recirculation before treatment, utilizing integrated blood and dialysate property detection units to assess cannula placement and shunt condition without additional bolus administration.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Measurement precision

If explicit bolus doses and blood sampling are used to detect recirculation, then recirculation detection accuracy is improved, but treatment disruption and invasiveness increase

Engineering Contradiction:
Improverecirculation detection accuracyVSAvoidtreatment disruption
Core Design Contradiction:
Measurement precisionVSEase of operation

Solution Approach 1:

The priming fluid serves dual purposes: it primes the extracorporeal blood circuit and acts as a tracer substance for recirculation detection. This eliminates the need for separate bolus administration and blood sampling procedures, thereby maintaining detection accuracy while avoiding treatment disruption

Inventive Principle:
Principle #6Universality (Multi-functionality)

Solution Approach 2:

Recirculation detection is performed during the priming phase before actual blood treatment begins. The priming fluid is administered in advance, allowing recirculation assessment to be completed prior to connecting the patient, thus eliminating interruptions during the treatment process

Inventive Principle:
Principle #10Preliminary action

2Reliability

If recirculation detection is performed during blood treatment, then recirculation can be identified, but treatment duration is prolonged

Engineering Contradiction:
Improverecirculation identificationVSAvoidtreatment duration
Core Design Contradiction:
ReliabilityVSLoss of time

Solution Approach 1:

The detection of recirculation is performed during the priming phase before blood treatment commences. By using the priming fluid already present in the circuit, the system identifies recirculation issues in advance, allowing corrective measures to be taken before patient connection and eliminating time loss during active treatment

Inventive Principle:
Principle #10Preliminary action

Solution Approach 2:

The priming fluid automatically serves as the tracer substance for recirculation detection without requiring additional interventions. The system utilizes the existing priming process to perform detection, making the treatment process self-sufficient and eliminating separate detection steps that would extend treatment duration

Inventive Principle:
Principle #25Self-service

3Measurement precision

If additional bolus administration is used for recirculation detection, then detection sensitivity is improved, but procedure complexity increases

Engineering Contradiction:
Improvedetection sensitivityVSAvoidprocedure complexity
Core Design Contradiction:
Measurement precisionVSDevice complexity

Solution Approach 1:

The priming fluid performs multiple functions simultaneously: circuit priming, flushing, and recirculation detection tracer. This consolidation eliminates the need for separate bolus administration procedures and complex detection protocols, thereby maintaining high detection sensitivity while simplifying the overall procedure

Inventive Principle:
Principle #6Universality (Multi-functionality)

Solution Approach 2:

The patent merges the priming process with the recirculation detection process by using the same fluid (priming fluid) for both purposes. This combination eliminates the need for additional bolus doses and separate sampling procedures, reducing procedural complexity while preserving detection sensitivity

Inventive Principle:
Principle #5Merging (Combining)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

Enables efficient and safe extracorporeal blood treatment by detecting and correcting recirculation before the start of therapy, minimizing disruption and ensuring correct cannula placement without additional interventions during the treatment.

Implementation Method 1

Within the dialyzer, the blood from the circulatory system and the dialysate from the dialysate circuit are brought into contact via a semipermeable membrane, allowing for the exchange of substances between the blood and the dialysate

Methodology Applied
Scientific EffectDiffusion: Diffusion

Implementation Method 2

dialysis treatment for patients with kidney failure removes toxins from the blood as well as excess water

Methodology Applied
Scientific EffectOsmosis: Osmosis

Data Source

PatentEP4681747A1Extracorporeal blood treatment machine, computer-implemented detection method, and computer program
Publication Date: 2026.01.21 B BRAUN AVITUM
  • EP4681747A1 patent drawingFigure 1
  • EP4681747A1 patent drawingFigure 2~3
  • EP4681747A1 patent drawingFigure 4

AI summary

The disclosure relates to an extracorporeal blood treatment machine (1) for extracorporeal blood treatment of blood of a patient (P) with a dialyzer (2), an extracorporeal blood circuit (5) comprising an arterial section (42) and a venous section (50), a dialyzing fluid circuit (3), a blood property detection unit (8) and/or a dialysate property detection unit (32), and a control unit (54) signal-connected to the blood property detection unit (8) and/or the dialysate property detection unit (32).The blood treatment machine (1) is configured, in preparation for extracorporeal blood treatment: to perform a priming (S1) of the extracorporeal blood circuit (5) with a priming fluid; to request and/or establish a connection (S3) of an arterial shunt segment (Sa) with the arterial segment (42) filled with priming fluid by the priming; to request and/or establish a connection (S7) of a venous shunt segment (Sv) with the venous segment (50) filled with priming fluid by the priming; and to detect and/or quantify and/or verify a recirculation (r) and/or a recirculation rate at the shunt (S) at least depending on a blood property (Br, Br', Br") and/or dialysate property (Dr, Dr') recorded after the connection (S7) of the venous shunt segment (Sv).In addition, the disclosure relates to a computer-implemented detection method and a computer program according to the subordinate claims.