Dialysis Sorbent Cartridge Intake Manifold Flow Control

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Solution Overview

Problem

Sorbent cartridge systems in dialysis experience non-uniform flow distribution, leading to inefficient treatment performance and premature exhaustion, as fluid flow tends to channel through peripheral regions rather than central areas, resulting in underused or unused material.

Innovation Solution

A sorbent cartridge system with a continuous sidewall and multiple layers of solid particulate media, where the intake manifold differentially controls fluid flow rates between central and peripheral regions, ensuring a higher flow rate in the central region compared to the peripheral region to prevent channeling and promote uniform usage of materials.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Manufacturing precision

If fluid flows through sorbent cartridge layers without differential flow control, then the system structure remains simple, but non-uniform flow distribution occurs causing peripheral channeling and central region underutilization

Engineering Contradiction:
Improveflow distribution uniformityVSAvoidmanifold configuration complexity
Core Design Contradiction:
Manufacturing precisionVSDevice complexity

Solution Approach 1:

The intake manifold is configured with multiple discharge ports that differentially control fluid flow rates to different regions of the sorbent cartridge. Central discharge ports provide higher flow rates to central regions, while peripheral discharge ports provide lower flow rates to peripheral regions. This local differentiation of flow quality compensates for the natural tendency toward peripheral channeling, achieving uniform flow distribution across the cartridge cross-section without requiring complex external control systems.

Inventive Principle:
Principle #3Local quality

2Productivity

If peripheral regions receive higher flow rates, then fluid flow follows the path of least resistance, but this causes premature exhaustion of peripheral material and reduces overall treatment performance

Engineering Contradiction:
Improvetreatment performance efficiencyVSAvoidsorbent material utilization
Core Design Contradiction:
ProductivityVSLoss of substance

Solution Approach 1:

The system applies preliminary anti-action by intentionally reducing the flow rate to peripheral regions before the natural channeling effect can cause premature material exhaustion. The intake manifold's peripheral discharge ports are configured to deliver lower flow rates to peripheral regions, counteracting the tendency of fluid to preferentially flow through these paths. This preemptive flow redistribution ensures that peripheral and central regions are utilized more evenly, maximizing sorbent material effectiveness and extending cartridge service life.

Inventive Principle:
Principle #9Preliminary anti-action

3Duration of action of stationary object

If uniform flow distribution is achieved through differential flow control, then material usage is optimized, but the manifold requires multiple discharge ports with different flow rate capabilities

Engineering Contradiction:
Improvecartridge useful lifeVSAvoidintake manifold structure
Core Design Contradiction:
Duration of action of stationary objectVSDevice complexity

Solution Approach 1:

The intake manifold is segmented into multiple discharge ports grouped by location (central and peripheral regions) and configured to deliver different flow rates. This segmentation allows the manifold to address the non-uniform flow distribution problem by treating different regions of the sorbent cartridge differently. The segmented discharge port configuration, while more complex than a single port, provides a practical and effective solution that significantly extends cartridge useful life through optimized material utilization.

Inventive Principle:
Principle #1Segmentation

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

This configuration enhances the efficiency and longevity of the sorbent cartridge by reducing unused material and preventing premature exhaustion, improving the overall performance and extending the useful life of the cartridge.

Implementation Method 1

The ammonia and ammonium ions are then removed by the zirconium phosphate in exchange for the hydrogen ions and Na+

Methodology Applied
Scientific EffectIon exchange: Ion Exchange

Implementation Method 2

The sorbent cartridge containing zirconium phosphate (ZrP) and hydrous zirconium oxide (HZO) ion-exchange materials

Methodology Applied
Scientific EffectIon exchange: Ion Exchange

Implementation Method 3

The membrane allows the wastes, electrolytes, and water to cross but restricts the passage of large molecular weight proteins and blood cells

Methodology Applied
Scientific EffectSize-based filtration: Filter (physical)

Data Source

PatentEP3352810B1Cartridge systems useful in cleaning dialysis solutions
Publication Date: 2020.04.08 FRESENIUS MEDICAL CARE HOLDINGS INC
  • EP3352810B1 patent drawingFigure 1
  • EP3352810B1 patent drawingFigure 2
  • EP3352810B1 patent drawingFigure 3

AI summary

Sorbent cartridge systems useful in regenerating or purifying dialysis solutions are described as well as methods to regenerate or purify spent dialysis solutions. Dialysis systems using the sorbent cartridge system of the present invention are further described.