Dialyzed White Rice Extract for Cell Proliferation
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Solution Overview
Problem
Current methods for proliferating cells, such as differentiated and stem cells, in regenerative medicine are inefficient in achieving large-scale cell proliferation and tissue repair in a short period, and existing rice water extracts have inhibitory substances that hinder their effectiveness.
Innovation Solution
Modifying the processing of white rice water extracts using dialysis with an 8K dialysis membrane to eliminate inhibitory substances, resulting in enhanced cell-proliferating and tissue-repairing agents that can be used as internal solutions, water extracts, saccharified products, or fermented products.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional water extracts of white rice are used, then biosafety is maintained, but cell-proliferating and tissue-repairing efficacy is inhibited by unwanted substances
Solution Approach 1:
The patent applies extraction by using dialysis to remove unwanted low-molecular-weight substances from the water extract of white rice. The dialysis process separates the desired high-molecular-weight cell-proliferating components from inhibitory low-molecular-weight substances, thereby eliminating the harmful factors while preserving the beneficial effects.
Solution Approach 2:
The patent changes the molecular weight distribution parameter of the rice extract by using dialysis with specific membrane cutoff values (8,000 or 14,000). This parameter change transforms the extract from containing both beneficial and harmful substances to containing only beneficial high-molecular-weight substances, thereby resolving the contradiction between safety and efficacy.
2Productivity
If dialysis treatment is applied to remove inhibitory substances, then cell-proliferating efficacy is improved, but processing complexity increases
Solution Approach 1:
The patent uses dialysis membrane as an intermediary tool to achieve separation of substances. The membrane acts as a mediator that selectively allows passage of low-molecular-weight inhibitory substances while retaining high-molecular-weight beneficial components, thereby simplifying the purification process compared to multiple conventional separation steps.
3Ease of operation
If conventional cell culture methods are used, then process simplicity is maintained, but time required for large-scale cell proliferation is excessive
Solution Approach 1:
The patent changes the chemical composition parameter of the culture medium by incorporating dialyzed rice extract enriched with specific high-molecular-weight components. This parameter change in the medium composition accelerates cell proliferation rate and enhances tissue-repairing activity, thereby reducing the time required for large-scale cell production while maintaining operational simplicity.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The modified rice-derived agents significantly enhance cell proliferation and tissue repair, offering greater efficacy compared to conventional extracts while maintaining high biosafety, allowing for both in vitro and in vivo applications.
Implementation Method 1
an internal solution produced by the dialysis of a water-treated product of a raw rice material essentially including a white rice fraction with an 8K dialysis membrane
Data Source
AI summary
Provided are more effective cell-proliferating and tissue-repairing agents derived from rice containing, as an active ingredient, an internal solution produced by the dialysis of a water-treated product of a raw rice material essentially including a white rice fraction with an 8K dialysis membrane.