Dialyzed Serum Cardiomyocyte Medium for Purity and Stability

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Solution Overview

Problem

Current methods for maintaining cardiomyocyte purity and modulating their electrical activity in cell cultures are inadequate, leading to challenges in regenerative medicine and drug screening, as existing protocols fail to ensure homogeneity and stability of cardiomyocyte populations.

Innovation Solution

A method involving the use of a medium essentially free of low molecular weight molecules and glucose, with optional dialyzed serum, to culture cardiomyocytes derived from induced pluripotent stem cells, which maintains cardiomyocyte purity and modulates their electrical activity by increasing beating frequency and reducing oscillations.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If conventional culture medium with serum and glucose is used, then cardiomyocytes can be maintained in culture, but the purity and homogeneity of cardiomyocyte population deteriorates over time

Engineering Contradiction:
Improvecardiomyocyte purityVSAvoidculture duration
Core Design Contradiction:
ReliabilityVSDuration of action of stationary object

Solution Approach 1:

The invention changes the chemical parameters of the culture medium by removing glucose and dialyzing serum to eliminate low molecular weight molecules. This parameter modification prevents the outgrowth of non-cardiomyocyte cells while maintaining cardiomyocyte viability and purity throughout extended culture periods

Inventive Principle:
Principle #35Parameter changes

Solution Approach 2:

The invention extracts and removes harmful components from the culture medium, specifically glucose and low molecular weight molecules from serum. This extraction eliminates the factors that cause non-cardiomyocyte cell proliferation and maintains culture homogeneity

Inventive Principle:
Principle #2Taking out (Extraction)

2Reliability

If conventional culture medium is used, then cardiomyocytes can be maintained, but electrical activity stability deteriorates

Engineering Contradiction:
Improveelectrical activity stabilityVSAvoidculture duration
Core Design Contradiction:
ReliabilityVSDuration of action of stationary object

Solution Approach 1:

The invention modifies the chemical composition parameters of the culture medium by eliminating glucose and low molecular weight molecules. This parameter change stabilizes the electrical activity of cardiomyocytes by preventing metabolic fluctuations and maintaining consistent cellular function throughout extended culture periods

Inventive Principle:
Principle #35Parameter changes

3Reliability

If serum is added to culture medium, then cardiomyocyte survival is improved, but low molecular weight molecules cause loss of purity

Engineering Contradiction:
Improvecardiomyocyte survivalVSAvoidpopulation homogeneity
Core Design Contradiction:
ReliabilityVSManufacturing precision

Solution Approach 1:

The invention extracts and removes low molecular weight molecules from serum through dialysis. This extraction preserves the beneficial survival factors in serum while eliminating the components that promote non-cardiomyocyte cell growth and maintain population homogeneity

Inventive Principle:
Principle #2Taking out (Extraction)

Solution Approach 2:

The invention changes the molecular weight distribution parameter of the serum components by dialysis. This parameter modification retains high molecular weight survival factors while removing low molecular weight molecules that cause loss of population homogeneity

Inventive Principle:
Principle #35Parameter changes

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

This approach effectively maintains cardiomyocyte purity for extended periods and stabilizes their beating frequency, enhancing their suitability for regenerative medicine and drug screening applications.

Implementation Method 1

the serum or the medium may be essentially free of low molecular weight molecules or may be essentially free of low molecular weight serum growth factors and other components. Particularly, the serum could be dialyzed with a membrane with molecular weight cutoff of 10 kD.

Methodology Applied
Scientific EffectDialysis: Diffusion

Data Source

PatentEP2582792B1Cardiomyocyte medium with dialyzed serum
Publication Date: 2018.10.31 FUJIFILM CELLULAR DYNAMICS INC
  • EP2582792B1 patent drawingFigure 1A~1B
  • EP2582792B1 patent drawingFigure 2A~2B
  • EP2582792B1 patent drawingFigure 2C~3

AI summary

Methods and composition for maintenance of cardiomyocytes are provided. For example, in certain aspects methods including culturing the cardiomyocytes in a medium essentially free of serum or containing dialyzed serum to maintain long-term purity. In further aspects, methods for modulation of cardiomyocytes may be provided.